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Controversy about pharmacological modulation of Nrf2 for cancer therapy

Conventional anticancer therapies such as radiotherapy and chemotherapies are associated with oxidative stress generating reactive oxygen species (ROS) and reactive aldehydes like 4-hydroxynonenal in cancer cells that govern them to die. The main mechanism activated due to exposure of the cell to th...

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Detalles Bibliográficos
Autores principales: Milkovic, Lidija, Zarkovic, Neven, Saso, Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393166/
https://www.ncbi.nlm.nih.gov/pubmed/28411557
http://dx.doi.org/10.1016/j.redox.2017.04.013