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Evaluation of the clinical value of bone metabolic parameters for the screening of osseous metastases compared to bone scintigraphy
BACKGROUND: Bone metastases are common in many types of cancer. As screening methods different imaging modalities are available. A new approach for the screening of osseous metastases represents the measurement of bone metabolic markers. Therefore aim of this study was to evaluate the usefulness of...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2004
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539349/ https://www.ncbi.nlm.nih.gov/pubmed/15579208 http://dx.doi.org/10.1186/1471-2385-4-3 |
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author | Schoenberger, Johann Rozeboom, Silke Wirthgen-Beyer, Eva Eilles, Christoph |
author_facet | Schoenberger, Johann Rozeboom, Silke Wirthgen-Beyer, Eva Eilles, Christoph |
author_sort | Schoenberger, Johann |
collection | PubMed |
description | BACKGROUND: Bone metastases are common in many types of cancer. As screening methods different imaging modalities are available. A new approach for the screening of osseous metastases represents the measurement of bone metabolic markers. Therefore aim of this study was to evaluate the usefulness of the determination of bone metabolic markers aminoterminal propeptide of type I procollagen (PINP, osteoblastic activity) and the carboxyterminal pyridinoline cross-linked telopeptide of type I collagen (ICTP, osteoclastic activity) for the detection of bone metastases associated with other malignancies. METHODS: 88 patients aged 21 – 82 years with malignant tumors were prospectively studied. The serum concentrations of PINP and ICTP were measured and compared to the results of bone scintigraphy, radiological bone series, CT, MRI and clinical follow-up. RESULTS: Osseous metastases were found in 21 patients. 19 of them were correctly identified by bone scintigraphy (sensitivity: 90%). For bone metabolic markers results were as follows: ICTP sensitivity: 71%, specificity: 42%; PINP sensitivity: 24%, specificity: 96%. CONCLUSIONS: As markers of bone metabolism PINP and ICTP showed low sensitivity and/or specificity for the detection of osseous metastases. The presented markers did not seem to be sufficient enough to identify patients with bone metastases or to replace established screening methods. |
format | Text |
id | pubmed-539349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-5393492005-01-01 Evaluation of the clinical value of bone metabolic parameters for the screening of osseous metastases compared to bone scintigraphy Schoenberger, Johann Rozeboom, Silke Wirthgen-Beyer, Eva Eilles, Christoph BMC Nucl Med Research Article BACKGROUND: Bone metastases are common in many types of cancer. As screening methods different imaging modalities are available. A new approach for the screening of osseous metastases represents the measurement of bone metabolic markers. Therefore aim of this study was to evaluate the usefulness of the determination of bone metabolic markers aminoterminal propeptide of type I procollagen (PINP, osteoblastic activity) and the carboxyterminal pyridinoline cross-linked telopeptide of type I collagen (ICTP, osteoclastic activity) for the detection of bone metastases associated with other malignancies. METHODS: 88 patients aged 21 – 82 years with malignant tumors were prospectively studied. The serum concentrations of PINP and ICTP were measured and compared to the results of bone scintigraphy, radiological bone series, CT, MRI and clinical follow-up. RESULTS: Osseous metastases were found in 21 patients. 19 of them were correctly identified by bone scintigraphy (sensitivity: 90%). For bone metabolic markers results were as follows: ICTP sensitivity: 71%, specificity: 42%; PINP sensitivity: 24%, specificity: 96%. CONCLUSIONS: As markers of bone metabolism PINP and ICTP showed low sensitivity and/or specificity for the detection of osseous metastases. The presented markers did not seem to be sufficient enough to identify patients with bone metastases or to replace established screening methods. BioMed Central 2004-12-04 /pmc/articles/PMC539349/ /pubmed/15579208 http://dx.doi.org/10.1186/1471-2385-4-3 Text en Copyright © 2004 Schoenberger et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Schoenberger, Johann Rozeboom, Silke Wirthgen-Beyer, Eva Eilles, Christoph Evaluation of the clinical value of bone metabolic parameters for the screening of osseous metastases compared to bone scintigraphy |
title | Evaluation of the clinical value of bone metabolic parameters for the screening of osseous metastases compared to bone scintigraphy |
title_full | Evaluation of the clinical value of bone metabolic parameters for the screening of osseous metastases compared to bone scintigraphy |
title_fullStr | Evaluation of the clinical value of bone metabolic parameters for the screening of osseous metastases compared to bone scintigraphy |
title_full_unstemmed | Evaluation of the clinical value of bone metabolic parameters for the screening of osseous metastases compared to bone scintigraphy |
title_short | Evaluation of the clinical value of bone metabolic parameters for the screening of osseous metastases compared to bone scintigraphy |
title_sort | evaluation of the clinical value of bone metabolic parameters for the screening of osseous metastases compared to bone scintigraphy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539349/ https://www.ncbi.nlm.nih.gov/pubmed/15579208 http://dx.doi.org/10.1186/1471-2385-4-3 |
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