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Effects of hyaluronic acid on bleeding following third molar extraction

OBJECTIVE: To explore the effects of hyaluronic acid (HA) on bleeding and associated outcomes after third molar extraction. METHODS: Forty patients who had undergone molar extraction were randomly divided into two groups; 0.8% (w/v) HA was applied to the HA group (n=20) whereas a control group (n=20...

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Detalles Bibliográficos
Autores principales: GOCMEN, Gokhan, AKTOP, Sertac, TÜZÜNER, Burcin, GOKER, Bahar, YARAT, Aysen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculdade De Odontologia De Bauru - USP 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393542/
https://www.ncbi.nlm.nih.gov/pubmed/28403362
http://dx.doi.org/10.1590/1678-77572015-0187
Descripción
Sumario:OBJECTIVE: To explore the effects of hyaluronic acid (HA) on bleeding and associated outcomes after third molar extraction. METHODS: Forty patients who had undergone molar extraction were randomly divided into two groups; 0.8% (w/v) HA was applied to the HA group (n=20) whereas a control group (n=20) was not treated. Salivary and gingival tissue factor (TF) levels, bleeding time, maximum interincisal opening (MIO), pain scored on a visual analog scale (VAS), and the swelling extent were compared between the two groups. RESULTS: HA did not significantly affect gingival TF levels. Salivary TF levels increased significantly 1 week after HA application but not in the control group. Neither the VAS pain level nor MIO differed significantly between the two groups. The swelling extent on day 3 and the bleeding time were greater in the HA group than in the control group. CONCLUSIONS: Local injection of HA at 0.8% prolonged the bleeding time, and increased hemorrhage and swelling in the early postoperative period after third molar extractions.