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Sequence variability of the respiratory syncytial virus (RSV) fusion gene among contemporary and historical genotypes of RSV/A and RSV/B

BACKGROUND: The fusion (F) protein of RSV is the major vaccine target. This protein undergoes a conformational change from pre-fusion to post-fusion. Both conformations share antigenic sites II and IV. Pre-fusion F has unique antigenic sites p27, ø, α2α3β3β4, and MPE8; whereas, post-fusion F has uni...

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Detalles Bibliográficos
Autores principales:	Hause, Anne M., Henke, David M., Avadhanula, Vasanthi, Shaw, Chad A., Tapia, Lorena I., Piedra, Pedro A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393888/ https://www.ncbi.nlm.nih.gov/pubmed/28414749 http://dx.doi.org/10.1371/journal.pone.0175792

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