Acquired CDK6 amplification promotes breast cancer resistance to CDK4/6 inhibitors and loss of ER signaling and dependence

Dysregulated activation of the CDK4/6 kinases is a hallmark of most mammary-derived carcinomas. ATP-competitive inhibitors against this complex have been recently advanced in the clinic and have shown significant activity, particularly against tumors driven by the estrogen receptor (ER). However, re...

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Detalles Bibliográficos
Autores principales: Yang, C, Li, Z, Bhatt, T, Dickler, M, Giri, D, Scaltriti, M, Baselga, J, Rosen, N, Chandarlapaty, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393973/
https://www.ncbi.nlm.nih.gov/pubmed/27748766
http://dx.doi.org/10.1038/onc.2016.379

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