Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer

Mammalian shelterin proteins POT1 and TPP1 form a stable heterodimer that protects chromosome ends and regulates telomerase-mediated telomere extension. However, how POT1 interacts with TPP1 remains unknown. Here we present the crystal structure of the C-terminal portion of human POT1 (POT1C) comple...

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Detalles Bibliográficos
Autores principales: Chen, Cong, Gu, Peili, Wu, Jian, Chen, Xianyun, Niu, Shuangshuang, Sun, Hong, Wu, Lijie, Li, Na, Peng, Junhui, Shi, Shaohua, Fan, Cuiying, Huang, Min, Wong, Catherine C. L., Gong, Qingguo, Kumar-Sinha, Chandan, Zhang, Rongguang, Pusztai, Lajos, Rai, Rekha, Chang, Sandy, Lei, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394241/
https://www.ncbi.nlm.nih.gov/pubmed/28393832
http://dx.doi.org/10.1038/ncomms14929

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