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Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer
Mammalian shelterin proteins POT1 and TPP1 form a stable heterodimer that protects chromosome ends and regulates telomerase-mediated telomere extension. However, how POT1 interacts with TPP1 remains unknown. Here we present the crystal structure of the C-terminal portion of human POT1 (POT1C) comple...
Autores principales: | Chen, Cong, Gu, Peili, Wu, Jian, Chen, Xianyun, Niu, Shuangshuang, Sun, Hong, Wu, Lijie, Li, Na, Peng, Junhui, Shi, Shaohua, Fan, Cuiying, Huang, Min, Wong, Catherine C. L., Gong, Qingguo, Kumar-Sinha, Chandan, Zhang, Rongguang, Pusztai, Lajos, Rai, Rekha, Chang, Sandy, Lei, Ming |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394241/ https://www.ncbi.nlm.nih.gov/pubmed/28393832 http://dx.doi.org/10.1038/ncomms14929 |
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