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Intracranial Lesions in Children and Adolescents with Morbid Obesity

BACKGROUND: Intracranial lesions may affect the hypothalamo-hypophyseal axis and lead to some neuro-endocrinological dysfunctions (hyperphagia, sleep disorders and hormonal dysfunctions). There is a very limited number of studies about childhood obesity and intracranial lesions. AIMS: To evaluate th...

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Autores principales: Törel Ergür, Ayça, Odabaşı Güneş, Sevinç, Tan, Sinan, Tandırcıoğlu, Ü. Ayşe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394290/
https://www.ncbi.nlm.nih.gov/pubmed/28418336
http://dx.doi.org/10.4274/balkanmedj.2015.1541
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author Törel Ergür, Ayça
Odabaşı Güneş, Sevinç
Tan, Sinan
Tandırcıoğlu, Ü. Ayşe
author_facet Törel Ergür, Ayça
Odabaşı Güneş, Sevinç
Tan, Sinan
Tandırcıoğlu, Ü. Ayşe
author_sort Törel Ergür, Ayça
collection PubMed
description BACKGROUND: Intracranial lesions may affect the hypothalamo-hypophyseal axis and lead to some neuro-endocrinological dysfunctions (hyperphagia, sleep disorders and hormonal dysfunctions). There is a very limited number of studies about childhood obesity and intracranial lesions. AIMS: To evaluate the incidence of intracranial lesions and its role in clinical symptoms and aetiology in cases with morbid obesity who have been admitted to the paediatric endocrinology department with this complaint. STUDY DESIGN: Cross-sectional study. METHODS: A total of 120 cases admitted to the paediatric endocrinology department with the complaint of morbid obesity between 2002 and 2015 were included in this study. A detailed history was taken and a physical examination was performed; biochemical, hormonal parameters were evaluated. Contrast dynamic magnetic resonance imaging was performed in order to visualize cranial pathologies. RESULTS: An intracranial lesions was detected in 16.6% of the patients and 55% of these lesions were adenoma of the hypophysis. Prolactin levels were increased in six patients but front hypophyseal hormone levels were within normal range in the rest of the patients. Growth velocity of the patients was not affected. CONCLUSION: In our study, the incidence of intracranial lesions in children and adolescents with morbid obesity was much higher than in the normal population. According to this data, we are of the opinion that contrast dynamic magnetic resonance imaging is helpful in children with morbid obesity for the early detection of the mass before it causes any clinical or neurological symptoms and in the prevention of future complications.
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spelling pubmed-53942902017-04-24 Intracranial Lesions in Children and Adolescents with Morbid Obesity Törel Ergür, Ayça Odabaşı Güneş, Sevinç Tan, Sinan Tandırcıoğlu, Ü. Ayşe Balkan Med J Original Article BACKGROUND: Intracranial lesions may affect the hypothalamo-hypophyseal axis and lead to some neuro-endocrinological dysfunctions (hyperphagia, sleep disorders and hormonal dysfunctions). There is a very limited number of studies about childhood obesity and intracranial lesions. AIMS: To evaluate the incidence of intracranial lesions and its role in clinical symptoms and aetiology in cases with morbid obesity who have been admitted to the paediatric endocrinology department with this complaint. STUDY DESIGN: Cross-sectional study. METHODS: A total of 120 cases admitted to the paediatric endocrinology department with the complaint of morbid obesity between 2002 and 2015 were included in this study. A detailed history was taken and a physical examination was performed; biochemical, hormonal parameters were evaluated. Contrast dynamic magnetic resonance imaging was performed in order to visualize cranial pathologies. RESULTS: An intracranial lesions was detected in 16.6% of the patients and 55% of these lesions were adenoma of the hypophysis. Prolactin levels were increased in six patients but front hypophyseal hormone levels were within normal range in the rest of the patients. Growth velocity of the patients was not affected. CONCLUSION: In our study, the incidence of intracranial lesions in children and adolescents with morbid obesity was much higher than in the normal population. According to this data, we are of the opinion that contrast dynamic magnetic resonance imaging is helpful in children with morbid obesity for the early detection of the mass before it causes any clinical or neurological symptoms and in the prevention of future complications. Galenos Publishing 2017-03 2017-03-28 /pmc/articles/PMC5394290/ /pubmed/28418336 http://dx.doi.org/10.4274/balkanmedj.2015.1541 Text en © Copyright 2017, Trakya University Faculty of Medicine http://creativecommons.org/licenses/by/2.5/ Balkan Medical Journal
spellingShingle Original Article
Törel Ergür, Ayça
Odabaşı Güneş, Sevinç
Tan, Sinan
Tandırcıoğlu, Ü. Ayşe
Intracranial Lesions in Children and Adolescents with Morbid Obesity
title Intracranial Lesions in Children and Adolescents with Morbid Obesity
title_full Intracranial Lesions in Children and Adolescents with Morbid Obesity
title_fullStr Intracranial Lesions in Children and Adolescents with Morbid Obesity
title_full_unstemmed Intracranial Lesions in Children and Adolescents with Morbid Obesity
title_short Intracranial Lesions in Children and Adolescents with Morbid Obesity
title_sort intracranial lesions in children and adolescents with morbid obesity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394290/
https://www.ncbi.nlm.nih.gov/pubmed/28418336
http://dx.doi.org/10.4274/balkanmedj.2015.1541
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