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Risk Adapted Management of Febrile Neutrepenia and Early Cessation of Empirical Antibiotherapy in Hematopoietic Stem Cell Transplantation Setting
BACKGROUND: Haematopoietic stem cell transplantation is a curative treatment option for many haematological disorders. Infection following haematopoietic stem cell transplantation is one of the major causes of mortality. AIMS: To investigate the outcomes of early cessation of empirical antibiotic tr...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394294/ https://www.ncbi.nlm.nih.gov/pubmed/28418340 http://dx.doi.org/10.4274/balkanmedj.2016.0012 |
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author | Kaya, Ali Hakan Tekgündüz, Emre Duygu, Fazilet Koca, Dicle Bekdemir, Filiz Batgi, Hikmetullah Ulu Uncu, Bahar Yiğenoğlu, Tuğçe Nur Dal, Mehmet Sinan Çakar Kızıl, Merih Altuntaş, Fevzi |
author_facet | Kaya, Ali Hakan Tekgündüz, Emre Duygu, Fazilet Koca, Dicle Bekdemir, Filiz Batgi, Hikmetullah Ulu Uncu, Bahar Yiğenoğlu, Tuğçe Nur Dal, Mehmet Sinan Çakar Kızıl, Merih Altuntaş, Fevzi |
author_sort | Kaya, Ali Hakan |
collection | PubMed |
description | BACKGROUND: Haematopoietic stem cell transplantation is a curative treatment option for many haematological disorders. Infection following haematopoietic stem cell transplantation is one of the major causes of mortality. AIMS: To investigate the outcomes of early cessation of empirical antibiotic treatment per protocol in febrile neutropenia patients who have undergone haematopoietic stem cell transplantation at our clinic. STUDY DESIGN: Descriptive study. METHODS: The present study retrospectively evaluated febrile neutropenia attacks in haematopoietic stem cell transplantation recipients during the period June 2014 - January 2015 at our haematopoietic stem cell transplantation clinic. RESULTS: A total of 72 febrile neutropenia attacks were evaluated in 53 patients. In 46 febrile neutropenia attacks, microbiologic cultures revealed positive results. In culture-positive febrile neutropenia episodes a single bacterium was isolated in 32 cases and multiple strains were isolated in 14. In 15 patients, empirical antibiotic therapy was discontinued after 72 hours. These patients were clinically stable, without evident focus of infection and had negative culture results. Only 4 recurrent episodes were observed (27%) after cessation of antibiotherapy. No patient died as a result of recurrent infection. The 30-day and 100-day post-transplantation mortality rates of patients with febrile neutropenia episodes were 11.3% (6/53) and 3.8% (2/53), respectively. Infection-related 30-day and 100-day mortality rates were 7.5% (4/53) and 0% (0/53), respectively. CONCLUSION: The main message of our study is that early cessation of empirical antibiotherapy seems to be feasible in eligible patients without increasing febrile neutropenia mortality rates. |
format | Online Article Text |
id | pubmed-5394294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-53942942017-04-24 Risk Adapted Management of Febrile Neutrepenia and Early Cessation of Empirical Antibiotherapy in Hematopoietic Stem Cell Transplantation Setting Kaya, Ali Hakan Tekgündüz, Emre Duygu, Fazilet Koca, Dicle Bekdemir, Filiz Batgi, Hikmetullah Ulu Uncu, Bahar Yiğenoğlu, Tuğçe Nur Dal, Mehmet Sinan Çakar Kızıl, Merih Altuntaş, Fevzi Balkan Med J Original Article BACKGROUND: Haematopoietic stem cell transplantation is a curative treatment option for many haematological disorders. Infection following haematopoietic stem cell transplantation is one of the major causes of mortality. AIMS: To investigate the outcomes of early cessation of empirical antibiotic treatment per protocol in febrile neutropenia patients who have undergone haematopoietic stem cell transplantation at our clinic. STUDY DESIGN: Descriptive study. METHODS: The present study retrospectively evaluated febrile neutropenia attacks in haematopoietic stem cell transplantation recipients during the period June 2014 - January 2015 at our haematopoietic stem cell transplantation clinic. RESULTS: A total of 72 febrile neutropenia attacks were evaluated in 53 patients. In 46 febrile neutropenia attacks, microbiologic cultures revealed positive results. In culture-positive febrile neutropenia episodes a single bacterium was isolated in 32 cases and multiple strains were isolated in 14. In 15 patients, empirical antibiotic therapy was discontinued after 72 hours. These patients were clinically stable, without evident focus of infection and had negative culture results. Only 4 recurrent episodes were observed (27%) after cessation of antibiotherapy. No patient died as a result of recurrent infection. The 30-day and 100-day post-transplantation mortality rates of patients with febrile neutropenia episodes were 11.3% (6/53) and 3.8% (2/53), respectively. Infection-related 30-day and 100-day mortality rates were 7.5% (4/53) and 0% (0/53), respectively. CONCLUSION: The main message of our study is that early cessation of empirical antibiotherapy seems to be feasible in eligible patients without increasing febrile neutropenia mortality rates. Galenos Publishing 2017-03 2017-03-28 /pmc/articles/PMC5394294/ /pubmed/28418340 http://dx.doi.org/10.4274/balkanmedj.2016.0012 Text en © Copyright 2017, Trakya University Faculty of Medicine http://creativecommons.org/licenses/by/2.5/ Balkan Medical Journal |
spellingShingle | Original Article Kaya, Ali Hakan Tekgündüz, Emre Duygu, Fazilet Koca, Dicle Bekdemir, Filiz Batgi, Hikmetullah Ulu Uncu, Bahar Yiğenoğlu, Tuğçe Nur Dal, Mehmet Sinan Çakar Kızıl, Merih Altuntaş, Fevzi Risk Adapted Management of Febrile Neutrepenia and Early Cessation of Empirical Antibiotherapy in Hematopoietic Stem Cell Transplantation Setting |
title | Risk Adapted Management of Febrile Neutrepenia and Early Cessation of Empirical Antibiotherapy in Hematopoietic Stem Cell Transplantation Setting |
title_full | Risk Adapted Management of Febrile Neutrepenia and Early Cessation of Empirical Antibiotherapy in Hematopoietic Stem Cell Transplantation Setting |
title_fullStr | Risk Adapted Management of Febrile Neutrepenia and Early Cessation of Empirical Antibiotherapy in Hematopoietic Stem Cell Transplantation Setting |
title_full_unstemmed | Risk Adapted Management of Febrile Neutrepenia and Early Cessation of Empirical Antibiotherapy in Hematopoietic Stem Cell Transplantation Setting |
title_short | Risk Adapted Management of Febrile Neutrepenia and Early Cessation of Empirical Antibiotherapy in Hematopoietic Stem Cell Transplantation Setting |
title_sort | risk adapted management of febrile neutrepenia and early cessation of empirical antibiotherapy in hematopoietic stem cell transplantation setting |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394294/ https://www.ncbi.nlm.nih.gov/pubmed/28418340 http://dx.doi.org/10.4274/balkanmedj.2016.0012 |
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