Cargando…

Microglia-Synapse Pathways: Promising Therapeutic Strategy for Alzheimer's Disease

The main hallmarks of Alzheimer's disease (AD) are extracellular deposits of amyloid plaques and intracellular accumulation of hyperphosphorylated neurofibrillary tangles (tau). However, the mechanisms underlying these neuropathological changes remain largely unclear. To date, plenty of studies...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Jingdun, Wang, Haitao, Lin, Ting, Bi, Bingtian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394358/ https://www.ncbi.nlm.nih.gov/pubmed/28473983 http://dx.doi.org/10.1155/2017/2986460

Ejemplares similares

Targeting Microglia-Synapse Interactions in Alzheimer’s Disease
por: Piccioni, Gaia, et al.
Publicado: (2021)

Synapses, Microglia, and Lipids in Alzheimer’s Disease
por: Paasila, Patrick J., et al.
Publicado: (2022)

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease
por: Colom-Cadena, Martí, et al.
Publicado: (2020)

Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease
por: Jia, Lin, et al.
Publicado: (2019)

Intersection of pathological tau and microglia at the synapse
por: Vogels, Thomas, et al.
Publicado: (2019)

Pathogenesis, therapeutic strategies and biomarker development based on “omics” analysis related to microglia in Alzheimer’s disease
por: Gao, Chao, et al.
Publicado: (2022)

Emerging Alzheimer’s disease therapeutics: promising insights from lipid metabolism and microglia-focused interventions
por: Tobeh, Nour S., et al.
Publicado: (2023)

Microglia and Synapse: Interactions in Health and Neurodegeneration
por: Šišková, Zuzana, et al.
Publicado: (2013)

Microglia in Alzheimer’s disease
por: Hansen, David V., et al.
Publicado: (2018)

Microglia and Alzheimer’s Disease
por: Merighi, Stefania, et al.
Publicado: (2022)

Targeting phosphodiesterase 4 as a potential therapeutic strategy for enhancing neuroplasticity following ischemic stroke
por: Wang, Haitao, et al.
Publicado: (2018)

Microglia in Alzheimer's Disease
por: Li, Ying, et al.
Publicado: (2014)

Identification of prognostic biomarkers and correlations with immune infiltrates among cGAS-STING in hepatocellular carcinoma
por: Qi, Zhenhua, et al.
Publicado: (2020)

Identifying circRNA–miRNA–mRNA Regulatory Networks in Chemotherapy-Induced Peripheral Neuropathy
por: Cao, Fei, et al.
Publicado: (2023)

Neural stem cells promote neuroplasticity: a promising therapeutic strategy for the treatment of Alzheimer’s disease
por: Chang, Jun, et al.
Publicado: (2023)

Nicotinic Acetylcholine Receptors and Microglia as Therapeutic and Imaging Targets in Alzheimer’s Disease
por: Takata, Kazuyuki, et al.
Publicado: (2022)

TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease Treatment
por: Zhou, Yongji, et al.
Publicado: (2020)

Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentials
por: Miao, Jifei, et al.
Publicado: (2023)

Alzheimer's disease: synapses gone cold
por: Koffie, Robert M, et al.
Publicado: (2011)

Microglia, Alzheimer's Disease, and Complement
por: Crehan, Helen, et al.
Publicado: (2012)

Microglia as hackers of the matrix: sculpting synapses and the extracellular space
por: Crapser, Joshua D., et al.
Publicado: (2021)

Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer’s Disease
por: Uddin, Md. Sahab, et al.
Publicado: (2020)

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8
por: Tzioras, Makis, et al.
Publicado: (2023)

The dynamics of monocytes and microglia in Alzheimer’s disease
por: Thériault, Peter, et al.
Publicado: (2015)

The Functions and Phenotypes of Microglia in Alzheimer’s Disease
por: Fujikawa, Risako, et al.
Publicado: (2023)

Microglia-Astrocyte Communication in Alzheimer’s Disease
por: Wu, Yingying, et al.
Publicado: (2023)

Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention
por: Zhang, Guimei, et al.
Publicado: (2021)

Activation of microglia bolsters synapse formation
por: Cristovão, Gonçalo, et al.
Publicado: (2014)

Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer’s Disease Pathogenesis?
por: Bruno, Lucrezia, et al.
Publicado: (2021)

Targeting Endothelin in Alzheimer's Disease: A Promising Therapeutic Approach
por: Sharma, Shiwali, et al.
Publicado: (2021)

Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer's Disease
por: Minocha, Tarun, et al.
Publicado: (2022)

Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models
por: Dejanovic, Borislav, et al.
Publicado: (2022)

Emerging insights into synapse dysregulation in Alzheimer’s disease
por: Martínez-Serra, Raquel, et al.
Publicado: (2022)

SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer’s disease
por: Brinkmalm, Ann, et al.
Publicado: (2014)

Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models
por: Rueda‐Carrasco, Javier, et al.
Publicado: (2023)

Multitarget therapeutic strategies for Alzheimer’s disease
por: Ibrahim, Mostafa M., et al.
Publicado: (2019)

The Biphasic Role of Microglia in Alzheimer's Disease
por: Mizuno, Tetsuya
Publicado: (2012)

Microglia and Wnt Pathways: Prospects for Inflammation in Alzheimer’s Disease
por: Yang, Yunying, et al.
Publicado: (2020)

Alzheimer’s Disease Research Using Human Microglia
por: Lue, Lih-Fen, et al.
Publicado: (2019)

Microglia in Alzheimer’s Disease in the Context of Tau Pathology
por: Perea, Juan Ramón, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_otf3b7jcev245mk3foi3lf6a9p