Cargando…

The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK–Receptor Interactions

The Janus kinases (JAKs) are non-receptor tyrosine kinases essential for signaling in response to cytokines and interferons and thereby control many essential functions in growth, development, and immune regulation. JAKs are unique among tyrosine kinases for their constitutive yet non-covalent assoc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferrao, Ryan, Lupardus, Patrick J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394478/ https://www.ncbi.nlm.nih.gov/pubmed/28458652 http://dx.doi.org/10.3389/fendo.2017.00071

Ejemplares similares

Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation
por: Ferrao, Ryan D, et al.
Publicado: (2018)

Crystal Structure of the FERM-SH2 Module of Human Jak2
por: McNally, Randall, et al.
Publicado: (2016)

The Janus kinases (Jaks)
por: Yamaoka, Kunihiro, et al.
Publicado: (2004)

Identification of a JAK2 FERM Domain Variant Associated With Hereditary Thrombocytosis
por: Müller, Jan, et al.
Publicado: (2021)

Translational Positioning of Janus Kinase (JAK) Inhibitors in Alopecia Areata
por: Blume-Peytavi, Ulrike, et al.
Publicado: (2015)

Immunohistochemistry of Janus Kinase 1 (JAK1) Expression in Vitiligo
por: Abdou, Asmaa Gaber, et al.
Publicado: (2018)

The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification
por: Shahi, Aashirwad, et al.
Publicado: (2022)

Mechanistic Insights into Regulation of JAK2 Tyrosine Kinase
por: Hubbard, Stevan R.
Publicado: (2018)

Differential regulation of Janus kinase 3 (JAK3) in bovine preovulatory follicles and identification of JAK3 interacting proteins in granulosa cells
por: Ndiaye, Kalidou, et al.
Publicado: (2016)

Selective Immunomodulation of Inflammatory Pathways in Keratinocytes by the Janus Kinase (JAK) Inhibitor Tofacitinib: Implications for the Employment of JAK-Targeting Drugs in Psoriasis
por: Morelli, Martina, et al.
Publicado: (2018)

Clinical Aspects of Janus Kinase (JAK) Inhibitors in the Cardiovascular System in Patients with Rheumatoid Arthritis
por: Kotyla, Przemysław J., et al.
Publicado: (2020)

Role of Janus Kinase (JAK) Inhibitor in Autoimmune Ocular Inflammation: A Systematic Review
por: Wen, Ji, et al.
Publicado: (2021)

Thromboembolic Adverse Drug Reactions in Janus Kinase (JAK) Inhibitors: Does the Inhibitor Specificity Play a Role?
por: Kotyla, Przemysław J., et al.
Publicado: (2021)

Essential functions of the Janus kinase 2 (Jak2) during mammary gland development and tumorigenesis
por: Sakamoto, K, et al.
Publicado: (2005)

Pseudocirrhosis in Chronic Budd Chiari Syndrome With Janus Tyrosine Kinase 2 (JAK2) Mutation
por: Lakshmanan, Seetha, et al.
Publicado: (2020)

Ab Initio Modeling and Experimental Assessment of Janus Kinase 2 (JAK2) Kinase-Pseudokinase Complex Structure
por: Wan, Xiaobo, et al.
Publicado: (2013)

The potential roles of JAK/STAT signaling in the progression of osteoarthritis
por: Zhou, Qingluo, et al.
Publicado: (2022)

Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells
Publicado: (1995)

Novel Therapeutic Options for People with Ulcerative Colitis: An Update on Recent Developments with Janus Kinase (JAK) Inhibitors
por: Troncone, Edoardo, et al.
Publicado: (2020)

COVID-19 and the potential of Janus family kinase (JAK) pathway inhibition: A novel treatment strategy
por: Khaledi, Mansoor, et al.
Publicado: (2022)

Interaction of JAK with steroid receptor function
por: Gupta, Nibedita, et al.
Publicado: (2013)

Versican G1 domain enhances adenoviral-mediated transgene expression and can be modulated by inhibitors of the Janus kinase (JAK)/STAT and Src family kinase pathways
por: Akinfenwa, Patricia Y., et al.
Publicado: (2017)

Association between Polymorphism in the Janus Kinase 2 (JAK2) Gene and Selected Performance Traits in Cattle and Sheep
por: Oster, Nicola, et al.
Publicado: (2023)

Genetic Alterations of the Thrombopoietin/MPL/JAK2 Axis Impacting Megakaryopoiesis
por: Plo, Isabelle, et al.
Publicado: (2017)

Mucosal Epithelial Jak Kinases in Health and Diseases
por: Kumar, Narendra, et al.
Publicado: (2021)

Energy expenditure in myelofibrosis patients treated with a JAK1/2 inhibitor
por: Tremblay, Douglas, et al.
Publicado: (2023)

Cooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F
por: Gäbler, Karoline, et al.
Publicado: (2013)

JAK out of the Box; The Rationale behind Janus Kinase Inhibitors in the COVID-19 setting, and their potential in obese and diabetic populations
por: Menshawey, Rahma, et al.
Publicado: (2020)

The JAK inhibitors: do they bring a paradigm shift for the management of rheumatic diseases?
por: Tanaka, Yoshiya
Publicado: (2019)

JAK Kinases in Health and Disease: An Update
por: Laurence, Arian, et al.
Publicado: (2012)

Structure of a pseudokinase domain switch that controls oncogenic activation of Jak kinases
por: Toms, Angela V., et al.
Publicado: (2013)

A Case Report of Large Bilateral Pulmonary Embolism in a Patient With Janus Kinase 2 (JAK2) Positive Mutation
por: Khan, Zahid, et al.
Publicado: (2022)

Janus Kinase 3 phosphorylation and the JAK/STAT pathway are positively modulated by follicle-stimulating hormone (FSH) in bovine granulosa cells
por: Zareifard, Amir, et al.
Publicado: (2023)

SH2 Domain Binding: Diverse FLVRs of Partnership
por: Jaber Chehayeb, Rachel, et al.
Publicado: (2020)

Structural Insights into the Interaction of Heme with Protein Tyrosine Kinase JAK2
por: Schmalohr, Benjamin Franz, et al.
Publicado: (2020)

Interferon-γ induces interleukin-6 production by neutrophils via the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway
por: Yoshida, Shuhei, et al.
Publicado: (2021)

Janus kinase (JAK) inhibitors significantly reduce the humoral vaccination response against SARS-CoV-2 in patients with rheumatoid arthritis
por: Schäfer, Arne, et al.
Publicado: (2022)

The role of the interferon/JAK-STAT axis in driving islet HLA-I hyperexpression in type 1 diabetes
por: Russell, Mark A., et al.
Publicado: (2023)

Tubulosine selectively inhibits JAK3 signalling by binding to the ATP‐binding site of the kinase of JAK3
por: Kim, Byung‐Hak, et al.
Publicado: (2020)

The Role of LNK (SH2B3) in the Regulation of JAK-STAT Signalling in Haematopoiesis
por: Morris, Rhiannon, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0b5lg3inun8ssnv5g8u891o34r