Neurodevelopmental Changes in Excitatory Synaptic Structure and Function in the Cerebral Cortex of Sanfilippo Syndrome IIIA Mice

Sanfilippo syndrome, MPS IIIA-D, results from deficits in lysosomal enzymes that specifically degrade heparan sulfate, a sulfated glycosaminoglycan. The accumulation of heparan sulfate results in neurological symptoms, culminating in extensive neurodegeneration and early death. To study the impact o...

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Detalles Bibliográficos
Autores principales: Dwyer, Chrissa A., Scudder, Samantha L., Lin, Ying, Dozier, Lara E., Phan, Dustin, Allen, Nicola J., Patrick, Gentry N., Esko, Jeffrey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394534/
https://www.ncbi.nlm.nih.gov/pubmed/28418018
http://dx.doi.org/10.1038/srep46576

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