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Group Cognitive Behavior Therapy Reversed Insula Subregions Functional Connectivity in Asthmatic Patients

Background: Group cognitive behavior therapy (GCBT) is an effective treatment in improving self-management behaviors and quality of life for asthmatic patients. However, the mechanisms by which GCBT improves asthma-related clinical symptoms remain unknown. Previous studies have indicated that insula...

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Autores principales: Zhang, Yuqun, Yang, Yuan, Bian, Rongrong, Yin, Yingying, Hou, Zhenghua, Yue, Yingying, Chen, Huanxin, Yuan, Yonggui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394595/
https://www.ncbi.nlm.nih.gov/pubmed/28458637
http://dx.doi.org/10.3389/fnagi.2017.00105
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author Zhang, Yuqun
Yang, Yuan
Bian, Rongrong
Yin, Yingying
Hou, Zhenghua
Yue, Yingying
Chen, Huanxin
Yuan, Yonggui
author_facet Zhang, Yuqun
Yang, Yuan
Bian, Rongrong
Yin, Yingying
Hou, Zhenghua
Yue, Yingying
Chen, Huanxin
Yuan, Yonggui
author_sort Zhang, Yuqun
collection PubMed
description Background: Group cognitive behavior therapy (GCBT) is an effective treatment in improving self-management behaviors and quality of life for asthmatic patients. However, the mechanisms by which GCBT improves asthma-related clinical symptoms remain unknown. Previous studies have indicated that insula is an important region involved in the neuropathology of asthma. Therefore, we examined the possible alteration of functional connectivity (FC) in insula subregions after GCBT in asthmatic patients. Methods: Forty-two asthmatic patients and 60 healthy controls (HCs) received resting-state functional magnetic resonance imaging (rs-fMRI) scan and clinical assessments, 17 asthmatic patients completed GCBT treatment consisting of 8 sessions, and then received rs-fMRI scan and clinical assessments. Results: Asthmatic patients had greater left ventral anterior insula (vAI) FC with the left cerebellum posterior lobe, right middle temporal gyrus, and bilateral anterior cingulate cortex (ACC), but less FC with bilateral postcentral gyrus, bilateral occipital lobe, and left precentral gyrus compared with HCs. FC between left posterior insula and left medial frontal gyrus also increased in the patients. In addition, right vAI showed increased FC with right caudate and left putamen. FC between right dorsal anterior insula (dAI) and left calcarine however decreased. The increase in FC in insula subregions were significantly improved following GCBT. FC between the left vAI connectivity and left postcentral gyrus was positively correlated with the percentage of improvement in 17-items Hamilton depression rating scale scores, and FC between the right dAI and left calcarine was negatively associated with the improvement percentage in asthma control test scores. Conclusions: This study in the first time demonstrated that GCBT led to significant improvement of FC between insula subregions and other brain regions. Clinical Trial Registration: An investigation of therapeutic mechanism in asthmatic patients: based on the results of Group Cognitive Behavioral Therapy (Registration number: ChiCTR-COC-15007442) (http://www.chictr.org.cn/usercenter.aspx).
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spelling pubmed-53945952017-04-28 Group Cognitive Behavior Therapy Reversed Insula Subregions Functional Connectivity in Asthmatic Patients Zhang, Yuqun Yang, Yuan Bian, Rongrong Yin, Yingying Hou, Zhenghua Yue, Yingying Chen, Huanxin Yuan, Yonggui Front Aging Neurosci Neuroscience Background: Group cognitive behavior therapy (GCBT) is an effective treatment in improving self-management behaviors and quality of life for asthmatic patients. However, the mechanisms by which GCBT improves asthma-related clinical symptoms remain unknown. Previous studies have indicated that insula is an important region involved in the neuropathology of asthma. Therefore, we examined the possible alteration of functional connectivity (FC) in insula subregions after GCBT in asthmatic patients. Methods: Forty-two asthmatic patients and 60 healthy controls (HCs) received resting-state functional magnetic resonance imaging (rs-fMRI) scan and clinical assessments, 17 asthmatic patients completed GCBT treatment consisting of 8 sessions, and then received rs-fMRI scan and clinical assessments. Results: Asthmatic patients had greater left ventral anterior insula (vAI) FC with the left cerebellum posterior lobe, right middle temporal gyrus, and bilateral anterior cingulate cortex (ACC), but less FC with bilateral postcentral gyrus, bilateral occipital lobe, and left precentral gyrus compared with HCs. FC between left posterior insula and left medial frontal gyrus also increased in the patients. In addition, right vAI showed increased FC with right caudate and left putamen. FC between right dorsal anterior insula (dAI) and left calcarine however decreased. The increase in FC in insula subregions were significantly improved following GCBT. FC between the left vAI connectivity and left postcentral gyrus was positively correlated with the percentage of improvement in 17-items Hamilton depression rating scale scores, and FC between the right dAI and left calcarine was negatively associated with the improvement percentage in asthma control test scores. Conclusions: This study in the first time demonstrated that GCBT led to significant improvement of FC between insula subregions and other brain regions. Clinical Trial Registration: An investigation of therapeutic mechanism in asthmatic patients: based on the results of Group Cognitive Behavioral Therapy (Registration number: ChiCTR-COC-15007442) (http://www.chictr.org.cn/usercenter.aspx). Frontiers Media S.A. 2017-04-18 /pmc/articles/PMC5394595/ /pubmed/28458637 http://dx.doi.org/10.3389/fnagi.2017.00105 Text en Copyright © 2017 Zhang, Yang, Bian, Yin, Hou, Yue, Chen and Yuan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhang, Yuqun
Yang, Yuan
Bian, Rongrong
Yin, Yingying
Hou, Zhenghua
Yue, Yingying
Chen, Huanxin
Yuan, Yonggui
Group Cognitive Behavior Therapy Reversed Insula Subregions Functional Connectivity in Asthmatic Patients
title Group Cognitive Behavior Therapy Reversed Insula Subregions Functional Connectivity in Asthmatic Patients
title_full Group Cognitive Behavior Therapy Reversed Insula Subregions Functional Connectivity in Asthmatic Patients
title_fullStr Group Cognitive Behavior Therapy Reversed Insula Subregions Functional Connectivity in Asthmatic Patients
title_full_unstemmed Group Cognitive Behavior Therapy Reversed Insula Subregions Functional Connectivity in Asthmatic Patients
title_short Group Cognitive Behavior Therapy Reversed Insula Subregions Functional Connectivity in Asthmatic Patients
title_sort group cognitive behavior therapy reversed insula subregions functional connectivity in asthmatic patients
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394595/
https://www.ncbi.nlm.nih.gov/pubmed/28458637
http://dx.doi.org/10.3389/fnagi.2017.00105
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