Involvement of Nrf2 in Ocular Diseases

The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role...

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Detalles Bibliográficos
Autores principales: Batliwala, Shehzad, Xavier, Christy, Liu, Yang, Wu, Hongli, Pang, Iok-Hou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394909/
https://www.ncbi.nlm.nih.gov/pubmed/28473877
http://dx.doi.org/10.1155/2017/1703810
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author Batliwala, Shehzad
Xavier, Christy
Liu, Yang
Wu, Hongli
Pang, Iok-Hou
author_facet Batliwala, Shehzad
Xavier, Christy
Liu, Yang
Wu, Hongli
Pang, Iok-Hou
author_sort Batliwala, Shehzad
collection PubMed
description The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system—the Keap1-Nrf2-ARE pathway—on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world.
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spelling pubmed-53949092017-05-04 Involvement of Nrf2 in Ocular Diseases Batliwala, Shehzad Xavier, Christy Liu, Yang Wu, Hongli Pang, Iok-Hou Oxid Med Cell Longev Review Article The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system—the Keap1-Nrf2-ARE pathway—on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world. Hindawi 2017 2017-03-27 /pmc/articles/PMC5394909/ /pubmed/28473877 http://dx.doi.org/10.1155/2017/1703810 Text en Copyright © 2017 Shehzad Batliwala et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Batliwala, Shehzad
Xavier, Christy
Liu, Yang
Wu, Hongli
Pang, Iok-Hou
Involvement of Nrf2 in Ocular Diseases
title Involvement of Nrf2 in Ocular Diseases
title_full Involvement of Nrf2 in Ocular Diseases
title_fullStr Involvement of Nrf2 in Ocular Diseases
title_full_unstemmed Involvement of Nrf2 in Ocular Diseases
title_short Involvement of Nrf2 in Ocular Diseases
title_sort involvement of nrf2 in ocular diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394909/
https://www.ncbi.nlm.nih.gov/pubmed/28473877
http://dx.doi.org/10.1155/2017/1703810
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AT liuyang involvementofnrf2inoculardiseases
AT wuhongli involvementofnrf2inoculardiseases
AT pangiokhou involvementofnrf2inoculardiseases

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