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GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the Fmr1 Knockout Mouse Model of Fragile X Syndrome

Fragile X syndrome is a genetic condition resulting from FMR1 gene mutation that leads to intellectual disability, autism-like symptoms, and sensory hypersensitivity. Arbaclofen, a GABA-B agonist, has shown efficacy in some individuals with FXS but has become unavailable after unsuccessful clinical...

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Detalles Bibliográficos
Autores principales:	Sinclair, D., Featherstone, R., Naschek, M., Nam, J., Du, A., Wright, S., Pance, K., Melnychenko, O., Weger, R., Akuzawa, S., Matsumoto, M., Siegel, S. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2017
Materias:	New Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394929/ https://www.ncbi.nlm.nih.gov/pubmed/28451631 http://dx.doi.org/10.1523/ENEURO.0380-16.2017

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