Altering the threshold of an excitable signal transduction network changes cell migratory modes

The diverse migratory modes displayed by different cell types are generally believed to be idiosyncratic. Here we show that the migratory behavior of Dictyostelium was switched from amoeboid to keratocyte-like and oscillatory modes by synthetically decreasing PIP2 levels or increasing Ras/Rap-relate...

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Detalles Bibliográficos
Autores principales: Miao, Yuchuan, Bhattacharya, Sayak, Edwards, Marc, Cai, Huaqing, Inoue, Takanari, Iglesias, Pablo A., Devreotes, Peter N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394931/
https://www.ncbi.nlm.nih.gov/pubmed/28346441
http://dx.doi.org/10.1038/ncb3495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394931/
https://www.ncbi.nlm.nih.gov/pubmed/28346441
http://dx.doi.org/10.1038/ncb3495

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