Cargando…

Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients

Deletions and mutations affecting lymphoid transcription factor IKZF1 (IKAROS) are associated with an increased relapse risk and poor outcome in B-cell precursor acute lymphoblastic leukemia. However, additional genetic events may either enhance or negate the effects of IKZF1 deletions on prognosis....

Descripción completa

Detalles Bibliográficos
Autores principales:	Scheijen, Blanca, Boer, Judith M., Marke, René, Tijchon, Esther, van Ingen Schenau, Dorette, Waanders, Esmé, van Emst, Liesbeth, van der Meer, Laurens T., Pieters, Rob, Escherich, Gabriele, Horstmann, Martin A., Sonneveld, Edwin, Venn, Nicola, Sutton, Rosemary, Dalla-Pozza, Luciano, Kuiper, Roland P., Hoogerbrugge, Peter M., den Boer, Monique L., van Leeuwen, Frank N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ferrata Storti Foundation 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394950/ https://www.ncbi.nlm.nih.gov/pubmed/27979924 http://dx.doi.org/10.3324/haematol.2016.153023

Ejemplares similares

Targeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial Skeleton
por: Tijchon, Esther, et al.
Publicado: (2015)

The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution
por: Waanders, Esmé, et al.
Publicado: (2012)

Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress
por: Yuniati, Laurensia, et al.
Publicado: (2015)

The many faces of IKZF1 in B-cell precursor acute lymphoblastic leukemia
por: Marke, René, et al.
Publicado: (2018)

Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways
por: Butler, Miriam, et al.
Publicado: (2022)

The Prognostic Effect of IKZF1 Deletions in ETV6::RUNX1 and High Hyperdiploid Childhood Acute Lymphoblastic Leukemia
por: Østergaard, Anna, et al.
Publicado: (2023)

Tumor suppressors BTG1 and BTG2: Beyond growth control
por: Yuniati, Laurensia, et al.
Publicado: (2018)

Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations
por: Antić, Željko, et al.
Publicado: (2020)

Upfront Treatment Influences the Composition of Genetic Alterations in Relapsed Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia
por: Yu, Jiangyan, et al.
Publicado: (2020)

COBL is a novel hotspot for IKZF1 deletions in childhood acute lymphoblastic leukemia
por: Lopes, Bruno Almeida, et al.
Publicado: (2016)

BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway
por: Butler, Miriam, et al.
Publicado: (2021)

ABL-class Genomic Breakpoint Q-PCR: A Patient-specific Approach for MRD Monitoring in Acute Lymphoblastic Leukemia
por: van Outersterp, Inge, et al.
Publicado: (2023)

Highly sensitive MRD tests for ALL based on the IKZF1 Δ3–6 microdeletion
por: Venn, N C, et al.
Publicado: (2012)

IKZF1 Deletions with COBL Breakpoints Are Not Driven by RAG-Mediated Recombination Events in Acute Lymphoblastic Leukemia
por: Lopes, Bruno A., et al.
Publicado: (2019)

Interference with pre-B-cell receptor signaling offers a therapeutic option for TCF3-rearranged childhood acute lymphoblastic leukemia
por: van der Veer, A, et al.
Publicado: (2014)

The clinical impact of IKZF1 mutation in acute myeloid leukemia
por: Zhang, Xiang, et al.
Publicado: (2023)

Minimal residual disease, long-term outcome, and IKZF1 deletions in children and adolescents with Down syndrome and acute lymphocytic leukaemia: a matched cohort study
por: Michels, Naomi, et al.
Publicado: (2021)

Tyrosine kinase fusion genes in pediatric BCR-ABL1-like acute lymphoblastic leukemia
por: Boer, Judith M., et al.
Publicado: (2016)

Unravelling the Sequential Interplay of Mutational Mechanisms during Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia
por: Antić, Željko, et al.
Publicado: (2021)

The specific distribution pattern of IKZF1 mutation in acute myeloid leukemia
por: Zhang, Xiang, et al.
Publicado: (2020)

Copy number alterations in B-cell development genes, drug resistance, and clinical outcome in pediatric B-cell precursor acute lymphoblastic leukemia
por: Steeghs, Elisabeth M. P., et al.
Publicado: (2019)

Impact of IKZF1 Deletions in the Prognosis of Childhood Acute Lymphoblastic Leukemia in Argentina
por: Felice, María Sara, et al.
Publicado: (2022)

Mutated IKZF1 is an independent marker of adverse risk in acute myeloid leukemia
por: Eckardt, Jan-Niklas, et al.
Publicado: (2023)

Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia
por: Wojtuszkiewicz, Anna, et al.
Publicado: (2015)

RAS pathway mutations as a predictive biomarker for treatment adaptation in pediatric B-cell precursor acute lymphoblastic leukemia
por: Jerchel, I S, et al.
Publicado: (2018)

A novel germline PAX5 single exon deletion in a pediatric patient with precursor B-cell leukemia
por: van Engelen, N., et al.
Publicado: (2023)

Prognostic impact of IKZF1 deletion in adults with common B-cell acute lymphoblastic leukemia
por: Yao, Qiu-Mei, et al.
Publicado: (2016)

Lenalidomide induces degradation of IKZF1 and IKZF3
por: Krönke, Jan, et al.
Publicado: (2014)

Effect of IKZF1 deletions on signal transduction pathways in Philadelphia chromosome negative pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
por: van der Sligte, Naomi E, et al.
Publicado: (2015)

Detection of Pathogenic Isoforms of IKZF1 in Leukemic Cell Lines and Acute Lymphoblastic Leukemia Samples: Identification of a Novel Truncated IKZF1 Transcript in SUP-B15
por: Zhao, Weiqiang, et al.
Publicado: (2020)

Emerging role of antiproliferative protein BTG1 and BTG2
por: Kim, Sang Hyeon, et al.
Publicado: (2022)

Clinical and Genetic Characteristics of IKZF1 Mutation in Chinese Children With B-Cell Acute Lymphoblastic Leukemia
por: Zhang, Jingying, et al.
Publicado: (2022)

JAK2 aberrations in childhood B-cell precursor acute lymphoblastic leukemia
por: Steeghs, Elisabeth M.P., et al.
Publicado: (2017)

An investigation of methylation pattern changes in the IKZF1 promoter in patients with childhood B-cell acute lymphoblastic leukemia
por: Rahmani, Mina, et al.
Publicado: (2019)

RAG1 high expression associated with IKZF1 dysfunction in adult B-cell acute lymphoblastic leukemia
por: Han, Qi, et al.
Publicado: (2019)

Novel GTF2I–PDGFRB and IKZF1–TYW1 fusions in pediatric leukemia with normal karyotype
por: Panagopoulos, Ioannis, et al.
Publicado: (2019)

High STAP1 expression in DUX4-rearranged cases is not suitable as therapeutic target in pediatric B-cell precursor acute lymphoblastic leukemia
por: Steeghs, Elisabeth M. P., et al.
Publicado: (2018)

An Allele of IKZF1 (Ikaros) Conferring Susceptibility to Childhood Acute Lymphoblastic Leukemia Protects Against Type 1 Diabetes
por: Swafford, Austin D.-E., et al.
Publicado: (2011)

Confirmation of Childhood Acute Lymphoblastic Leukemia Variants, ARID5B and IKZF1, and Interaction with Parental Environmental Exposures
por: Evans, Tiffany-Jane, et al.
Publicado: (2014)

IKZF1 deletion is associated with a poor outcome in pediatric B-cell precursor acute lymphoblastic leukemia in Japan
por: Asai, Daisuke, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_0t4jkra7k08kojlisbibote6u4