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Gfi1b controls integrin signaling-dependent cytoskeleton dynamics and organization in megakaryocytes

Mutations in GFI1B are associated with inherited bleeding disorders called GFI1B-related thrombocytopenias. We show here that mice with a megakaryocyte-specific Gfi1b deletion exhibit a macrothrombocytopenic phenotype along a megakaryocytic dysplasia reminiscent of GFI1B-related thrombocytopenia. GF...

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Detalles Bibliográficos
Autores principales:	Beauchemin, Hugues, Shooshtarizadeh, Peiman, Vadnais, Charles, Vassen, Lothar, Pastore, Yves D, Möröy, Tarik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ferrata Storti Foundation 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394960/ https://www.ncbi.nlm.nih.gov/pubmed/28082345 http://dx.doi.org/10.3324/haematol.2016.150375

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