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Aberrant let7a/HMGA2 signaling activity with unique clinical phenotype in JAK2-mutated myeloproliferative neoplasms
High mobility group AT-hook 2 (HMGA2) is an architectural transcription factor that is negatively regulated by let-7 microRNA through binding to it’s 3′-untranslated region. Transgenic mice expressing Hmga2 with a truncation of its 3′-untranslated region has been shown to exhibit a myeloproliferativ...
Autores principales: | Chen, Chih-Cheng, You, Jie-Yu, Lung, Jrhau, Huang, Cih-En, Chen, Yi-Yang, Leu, Yu-Wei, Ho, Hsing-Ying, Li, Chian-Pei, Lu, Chang-Hsien, Lee, Kuan-Der, Hsu, Chia-Chen, Gau, Jyh-Pyng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ferrata Storti Foundation
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394969/ https://www.ncbi.nlm.nih.gov/pubmed/28057739 http://dx.doi.org/10.3324/haematol.2016.154385 |
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