Aberrant let7a/HMGA2 signaling activity with unique clinical phenotype in JAK2-mutated myeloproliferative neoplasms

High mobility group AT-hook 2 (HMGA2) is an architectural transcription factor that is negatively regulated by let-7 microRNA through binding to it’s 3′-untranslated region. Transgenic mice expressing Hmga2 with a truncation of its 3′-untranslated region has been shown to exhibit a myeloproliferativ...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Chih-Cheng, You, Jie-Yu, Lung, Jrhau, Huang, Cih-En, Chen, Yi-Yang, Leu, Yu-Wei, Ho, Hsing-Ying, Li, Chian-Pei, Lu, Chang-Hsien, Lee, Kuan-Der, Hsu, Chia-Chen, Gau, Jyh-Pyng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394969/
https://www.ncbi.nlm.nih.gov/pubmed/28057739
http://dx.doi.org/10.3324/haematol.2016.154385

Ejemplares similares

Ejemplares similares