CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response

Relapsed acute lymphoblastic leukemia is the most common cause of cancer-related mortality in young people and new therapeutic strategies are needed to improve outcome. Recent studies have shown that heterozygous inactivating mutations in the histone acetyl transferase, CREBBP, are particularly freq...

Descripción completa

Detalles Bibliográficos
Autores principales: Dixon, Zach A., Nicholson, Lindsay, Zeppetzauer, Martin, Matheson, Elizabeth, Sinclair, Paul, Harrison, Christine J., Irving, Julie A.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395114/
https://www.ncbi.nlm.nih.gov/pubmed/27979926
http://dx.doi.org/10.3324/haematol.2016.145177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395114/
https://www.ncbi.nlm.nih.gov/pubmed/27979926
http://dx.doi.org/10.3324/haematol.2016.145177

Ejemplares similares