The intracellular innate immune sensor NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth

Inflammatory bowel diseases involve the dynamic interplay of host genetics, microbiome and inflammatory response. Here, we report that NLRP12, a negative regulator of innate immunity, is reduced in human ulcerative colitis by comparing monozygotic twins and other patient cohorts. In parallel, Nlrp12...

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Detalles Bibliográficos
Autores principales: Chen, Liang, Wilson, Justin E., Koenigsknecht, Mark J., Chou, Wei-Chun, Montgomery, Stephanie A., Truax, Agnieszka D., Brickey, W. June, Packey, Christopher D., Maharshak, Nitsan, Matsushima, Glenn K., Plevy, Scott E., Young, Vincent B., Sartor, R. Balfour, Ting, Jenny P-Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395345/
https://www.ncbi.nlm.nih.gov/pubmed/28288099
http://dx.doi.org/10.1038/ni.3690

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