DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling

Mice lacking DIX domain containing-1 (DIXDC1), an intracellular Wnt/β-catenin signal pathway protein, have abnormal measures of anxiety, depression and social behavior. Pyramidal neurons in these animals’ brains have reduced dendritic spines and glutamatergic synapses. Treatment with lithium or a Gl...

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Detalles Bibliográficos
Autores principales: Martin, Pierre-Marie, Stanley, Robert E., Ross, Adam P., Freitas, Andiara E., Moyer, Caitlin E., Brumback, Audrey C., Iafrati, Jillian, Stapornwongkul, Kristina S., Dominguez, Sky, Kivimäe, Saul, Mulligan, Kimberly A., Pirooznia, Mehdi, McCombie, W. Richard, Potash, James B., Zandi, Peter P., Purcell, Shaun M., Sanders, Stephan J., Zuo, Yi, Sohal, Vikaas S., Cheyette, Benjamin N.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395363/
https://www.ncbi.nlm.nih.gov/pubmed/27752079
http://dx.doi.org/10.1038/mp.2016.184

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