Inhibition of STEP(61) ameliorates deficits in mouse and hiPSC-based schizophrenia models

The brain-specific tyrosine phosphatase, STEP (STriatal-Enriched protein tyrosine Phosphatase) is an important regulator of synaptic function. STEP normally opposes synaptic strengthening by increasing N-methyl D-aspartate glutamate receptor (NMDAR) internalization through dephosphorylation of GluN2...

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Detalles Bibliográficos
Autores principales: Xu, J, Hartley, B J, Kurup, P, Phillips, A, Topol, A, Xu, M, Ononenyi, C, Foscue, E, Ho, S-M, Baguley, T D, Carty, N, Barros, C S, Müller, U, Gupta, S, Gochman, P, Rapoport, J, Ellman, J A, Pittenger, C, Aronow, B, Nairn, A C, Nestor, M W, Lombroso, P J, Brennand, K J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395367/
https://www.ncbi.nlm.nih.gov/pubmed/27752082
http://dx.doi.org/10.1038/mp.2016.163

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