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Signal Enhancement in the HPLC-ESI-MS/MS analysis of spironolactone and its metabolites using HFIP and NH(4)F as eluent additives

This paper describes an LC-MS/MS method to determine the concentration of spironolactone and its metabolites 7-alpha-methylthiospironolactone and canrenone in blood plasma samples. The resulting assay is simple (using protein precipitation for sample preparation) and sensitive (the lower limit of qu...

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Detalles Bibliográficos
Autores principales:	Takkis, Kalev, Aro, Rudolf, Kõrgvee, Lenne-Triin, Varendi, Heili, Lass, Jana, Herodes, Koit, Kipper, Karin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395588/ https://www.ncbi.nlm.nih.gov/pubmed/28224249 http://dx.doi.org/10.1007/s00216-017-0255-4

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