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Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study
OBJECTIVE: This study aimed at investigating the association between the rs7903146 (C/T) polymorphism of the TCF7L2 gene with obesity in a Cameroonian population. METHOD: This was a case-control pilot study including 61 obese and 61 non-obese Cameroonian adults. Anthropometric indices of obesity, bl...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395748/ https://www.ncbi.nlm.nih.gov/pubmed/28420445 http://dx.doi.org/10.1186/s41043-017-0087-z |
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author | Nguimmo-Metsadjio, Aurelie Atogho-Tiedeu, Barbara Noubiap, Jean Jacques N. Evehe, Marie-Solange Djokam-Dadjeu, Rosine Donfack, Olivier Sontsa Nanfa, Dieudonne Mato, Edith Pascale M. Ngwa, Elvis Ndonwi Guewo-Fokeng, Magellan Pokam-Fosso, Priscille Mbacham, Wilfred F. Mbanya, Jean Claude Sobngwi, Eugene |
author_facet | Nguimmo-Metsadjio, Aurelie Atogho-Tiedeu, Barbara Noubiap, Jean Jacques N. Evehe, Marie-Solange Djokam-Dadjeu, Rosine Donfack, Olivier Sontsa Nanfa, Dieudonne Mato, Edith Pascale M. Ngwa, Elvis Ndonwi Guewo-Fokeng, Magellan Pokam-Fosso, Priscille Mbacham, Wilfred F. Mbanya, Jean Claude Sobngwi, Eugene |
author_sort | Nguimmo-Metsadjio, Aurelie |
collection | PubMed |
description | OBJECTIVE: This study aimed at investigating the association between the rs7903146 (C/T) polymorphism of the TCF7L2 gene with obesity in a Cameroonian population. METHOD: This was a case-control pilot study including 61 obese and 61 non-obese Cameroonian adults. Anthropometric indices of obesity, blood pressure, fasting blood glucose, and blood lipids were measured. The rs7903146 (C/T) polymorphism of the TCF7L2 gene was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and genotypes were correlated with clinical and biological parameters. RESULTS: The T allele was predominant in the study population with a frequency of 93%. No statistically significant difference was however observed between the genotypic (p = 0.50) and allelic frequencies (p = 0.58) of obese and non-obese subjects. Comparison of clinical and biochemical parameters of C allele carriers (CX = CC + CT) with those of TT genotype showed that there was no significant difference between the lipid profile of these two groups. CONCLUSION: The rs7903146 (C/T) polymorphism of the TCF7L2 gene might not be associated with obesity in the Cameroonian population. |
format | Online Article Text |
id | pubmed-5395748 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-53957482017-04-21 Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study Nguimmo-Metsadjio, Aurelie Atogho-Tiedeu, Barbara Noubiap, Jean Jacques N. Evehe, Marie-Solange Djokam-Dadjeu, Rosine Donfack, Olivier Sontsa Nanfa, Dieudonne Mato, Edith Pascale M. Ngwa, Elvis Ndonwi Guewo-Fokeng, Magellan Pokam-Fosso, Priscille Mbacham, Wilfred F. Mbanya, Jean Claude Sobngwi, Eugene J Health Popul Nutr Short Report OBJECTIVE: This study aimed at investigating the association between the rs7903146 (C/T) polymorphism of the TCF7L2 gene with obesity in a Cameroonian population. METHOD: This was a case-control pilot study including 61 obese and 61 non-obese Cameroonian adults. Anthropometric indices of obesity, blood pressure, fasting blood glucose, and blood lipids were measured. The rs7903146 (C/T) polymorphism of the TCF7L2 gene was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and genotypes were correlated with clinical and biological parameters. RESULTS: The T allele was predominant in the study population with a frequency of 93%. No statistically significant difference was however observed between the genotypic (p = 0.50) and allelic frequencies (p = 0.58) of obese and non-obese subjects. Comparison of clinical and biochemical parameters of C allele carriers (CX = CC + CT) with those of TT genotype showed that there was no significant difference between the lipid profile of these two groups. CONCLUSION: The rs7903146 (C/T) polymorphism of the TCF7L2 gene might not be associated with obesity in the Cameroonian population. BioMed Central 2017-04-18 /pmc/articles/PMC5395748/ /pubmed/28420445 http://dx.doi.org/10.1186/s41043-017-0087-z Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Short Report Nguimmo-Metsadjio, Aurelie Atogho-Tiedeu, Barbara Noubiap, Jean Jacques N. Evehe, Marie-Solange Djokam-Dadjeu, Rosine Donfack, Olivier Sontsa Nanfa, Dieudonne Mato, Edith Pascale M. Ngwa, Elvis Ndonwi Guewo-Fokeng, Magellan Pokam-Fosso, Priscille Mbacham, Wilfred F. Mbanya, Jean Claude Sobngwi, Eugene Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study |
title | Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study |
title_full | Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study |
title_fullStr | Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study |
title_full_unstemmed | Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study |
title_short | Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study |
title_sort | investigation of the association between the tcf7l2 rs7903146 (c/t) gene polymorphism and obesity in a cameroonian population: a pilot study |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395748/ https://www.ncbi.nlm.nih.gov/pubmed/28420445 http://dx.doi.org/10.1186/s41043-017-0087-z |
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