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Findings in young adults at colonoscopy from a hospital service database audit
BACKGROUND: Colorectal cancer (CRC) diagnosed at <50 years is predominantly located in the distal colon and rectum. Little is known about which lesion subtypes may serve as CRC precursors in young adults. The aim of this work was to document the prevalence and histological subtype of lesions seen...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395776/ https://www.ncbi.nlm.nih.gov/pubmed/28424049 http://dx.doi.org/10.1186/s12876-017-0612-y |
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author | Wong, Stephanie Lidums, Ilmars Rosty, Christophe Ruszkiewicz, Andrew Parry, Susan Win, Aung Ko Tomita, Yoko Vatandoust, Sina Townsend, Amanda Patel, Dainik Hardingham, Jennifer E. Roder, David Smith, Eric Drew, Paul Marker, Julie Uylaki, Wendy Hewett, Peter Worthley, Daniel L. Symonds, Erin Young, Graeme P. Price, Timothy J. Young, Joanne P. |
author_facet | Wong, Stephanie Lidums, Ilmars Rosty, Christophe Ruszkiewicz, Andrew Parry, Susan Win, Aung Ko Tomita, Yoko Vatandoust, Sina Townsend, Amanda Patel, Dainik Hardingham, Jennifer E. Roder, David Smith, Eric Drew, Paul Marker, Julie Uylaki, Wendy Hewett, Peter Worthley, Daniel L. Symonds, Erin Young, Graeme P. Price, Timothy J. Young, Joanne P. |
author_sort | Wong, Stephanie |
collection | PubMed |
description | BACKGROUND: Colorectal cancer (CRC) diagnosed at <50 years is predominantly located in the distal colon and rectum. Little is known about which lesion subtypes may serve as CRC precursors in young adults. The aim of this work was to document the prevalence and histological subtype of lesions seen in patients aged <50 years, and any associated clinical features. METHODS: An audit of the colonoscopy database at The Queen Elizabeth Hospital in Adelaide, South Australia over a 12-month period was undertaken. Findings were recorded from both colonoscopy reports and corresponding histological examination of excised lesions. RESULTS: Data were extracted from colonoscopies in 2064 patients. Those aged <50 comprised 485 (24%) of the total. CRC precursor lesions (including sessile serrated adenoma/polyps (SSA/P), traditional serrated adenomas, tubular adenomas ≥10 mm or with high-grade dysplasia, and conventional adenomas with villous histology) were seen in 4.3% of patients aged <50 and 12.9% of patients aged ≥50 (P <0.001). Among colonoscopies yielding CRC precursor lesions in patients under 50 years, SSA/P occurred in 52% of procedures (11/21), compared with 27% (55/204) of procedures in patients aged 50 and older (P = 0.02). SSA/P were proximally located in (10/11) 90% of patients aged under 50, and 80% (43/54) of those aged 50 and older (P = 0.46). CONCLUSIONS: SSA/P were the most frequently observed CRC precursor lesions in patients aged <50. Most CRCs in this age group are known to arise in the distal colon and rectum suggesting that lesions other than SSA/P may serve as the precursor for the majority of early-onset CRC. |
format | Online Article Text |
id | pubmed-5395776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-53957762017-04-20 Findings in young adults at colonoscopy from a hospital service database audit Wong, Stephanie Lidums, Ilmars Rosty, Christophe Ruszkiewicz, Andrew Parry, Susan Win, Aung Ko Tomita, Yoko Vatandoust, Sina Townsend, Amanda Patel, Dainik Hardingham, Jennifer E. Roder, David Smith, Eric Drew, Paul Marker, Julie Uylaki, Wendy Hewett, Peter Worthley, Daniel L. Symonds, Erin Young, Graeme P. Price, Timothy J. Young, Joanne P. BMC Gastroenterol Research Article BACKGROUND: Colorectal cancer (CRC) diagnosed at <50 years is predominantly located in the distal colon and rectum. Little is known about which lesion subtypes may serve as CRC precursors in young adults. The aim of this work was to document the prevalence and histological subtype of lesions seen in patients aged <50 years, and any associated clinical features. METHODS: An audit of the colonoscopy database at The Queen Elizabeth Hospital in Adelaide, South Australia over a 12-month period was undertaken. Findings were recorded from both colonoscopy reports and corresponding histological examination of excised lesions. RESULTS: Data were extracted from colonoscopies in 2064 patients. Those aged <50 comprised 485 (24%) of the total. CRC precursor lesions (including sessile serrated adenoma/polyps (SSA/P), traditional serrated adenomas, tubular adenomas ≥10 mm or with high-grade dysplasia, and conventional adenomas with villous histology) were seen in 4.3% of patients aged <50 and 12.9% of patients aged ≥50 (P <0.001). Among colonoscopies yielding CRC precursor lesions in patients under 50 years, SSA/P occurred in 52% of procedures (11/21), compared with 27% (55/204) of procedures in patients aged 50 and older (P = 0.02). SSA/P were proximally located in (10/11) 90% of patients aged under 50, and 80% (43/54) of those aged 50 and older (P = 0.46). CONCLUSIONS: SSA/P were the most frequently observed CRC precursor lesions in patients aged <50. Most CRCs in this age group are known to arise in the distal colon and rectum suggesting that lesions other than SSA/P may serve as the precursor for the majority of early-onset CRC. BioMed Central 2017-04-19 /pmc/articles/PMC5395776/ /pubmed/28424049 http://dx.doi.org/10.1186/s12876-017-0612-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Wong, Stephanie Lidums, Ilmars Rosty, Christophe Ruszkiewicz, Andrew Parry, Susan Win, Aung Ko Tomita, Yoko Vatandoust, Sina Townsend, Amanda Patel, Dainik Hardingham, Jennifer E. Roder, David Smith, Eric Drew, Paul Marker, Julie Uylaki, Wendy Hewett, Peter Worthley, Daniel L. Symonds, Erin Young, Graeme P. Price, Timothy J. Young, Joanne P. Findings in young adults at colonoscopy from a hospital service database audit |
title | Findings in young adults at colonoscopy from a hospital service database audit |
title_full | Findings in young adults at colonoscopy from a hospital service database audit |
title_fullStr | Findings in young adults at colonoscopy from a hospital service database audit |
title_full_unstemmed | Findings in young adults at colonoscopy from a hospital service database audit |
title_short | Findings in young adults at colonoscopy from a hospital service database audit |
title_sort | findings in young adults at colonoscopy from a hospital service database audit |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395776/ https://www.ncbi.nlm.nih.gov/pubmed/28424049 http://dx.doi.org/10.1186/s12876-017-0612-y |
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