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Findings in young adults at colonoscopy from a hospital service database audit

BACKGROUND: Colorectal cancer (CRC) diagnosed at <50 years is predominantly located in the distal colon and rectum. Little is known about which lesion subtypes may serve as CRC precursors in young adults. The aim of this work was to document the prevalence and histological subtype of lesions seen...

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Autores principales: Wong, Stephanie, Lidums, Ilmars, Rosty, Christophe, Ruszkiewicz, Andrew, Parry, Susan, Win, Aung Ko, Tomita, Yoko, Vatandoust, Sina, Townsend, Amanda, Patel, Dainik, Hardingham, Jennifer E., Roder, David, Smith, Eric, Drew, Paul, Marker, Julie, Uylaki, Wendy, Hewett, Peter, Worthley, Daniel L., Symonds, Erin, Young, Graeme P., Price, Timothy J., Young, Joanne P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395776/
https://www.ncbi.nlm.nih.gov/pubmed/28424049
http://dx.doi.org/10.1186/s12876-017-0612-y
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author Wong, Stephanie
Lidums, Ilmars
Rosty, Christophe
Ruszkiewicz, Andrew
Parry, Susan
Win, Aung Ko
Tomita, Yoko
Vatandoust, Sina
Townsend, Amanda
Patel, Dainik
Hardingham, Jennifer E.
Roder, David
Smith, Eric
Drew, Paul
Marker, Julie
Uylaki, Wendy
Hewett, Peter
Worthley, Daniel L.
Symonds, Erin
Young, Graeme P.
Price, Timothy J.
Young, Joanne P.
author_facet Wong, Stephanie
Lidums, Ilmars
Rosty, Christophe
Ruszkiewicz, Andrew
Parry, Susan
Win, Aung Ko
Tomita, Yoko
Vatandoust, Sina
Townsend, Amanda
Patel, Dainik
Hardingham, Jennifer E.
Roder, David
Smith, Eric
Drew, Paul
Marker, Julie
Uylaki, Wendy
Hewett, Peter
Worthley, Daniel L.
Symonds, Erin
Young, Graeme P.
Price, Timothy J.
Young, Joanne P.
author_sort Wong, Stephanie
collection PubMed
description BACKGROUND: Colorectal cancer (CRC) diagnosed at <50 years is predominantly located in the distal colon and rectum. Little is known about which lesion subtypes may serve as CRC precursors in young adults. The aim of this work was to document the prevalence and histological subtype of lesions seen in patients aged <50 years, and any associated clinical features. METHODS: An audit of the colonoscopy database at The Queen Elizabeth Hospital in Adelaide, South Australia over a 12-month period was undertaken. Findings were recorded from both colonoscopy reports and corresponding histological examination of excised lesions. RESULTS: Data were extracted from colonoscopies in 2064 patients. Those aged <50 comprised 485 (24%) of the total. CRC precursor lesions (including sessile serrated adenoma/polyps (SSA/P), traditional serrated adenomas, tubular adenomas ≥10 mm or with high-grade dysplasia, and conventional adenomas with villous histology) were seen in 4.3% of patients aged <50 and 12.9% of patients aged ≥50 (P <0.001). Among colonoscopies yielding CRC precursor lesions in patients under 50 years, SSA/P occurred in 52% of procedures (11/21), compared with 27% (55/204) of procedures in patients aged 50 and older (P = 0.02). SSA/P were proximally located in (10/11) 90% of patients aged under 50, and 80% (43/54) of those aged 50 and older (P = 0.46). CONCLUSIONS: SSA/P were the most frequently observed CRC precursor lesions in patients aged <50. Most CRCs in this age group are known to arise in the distal colon and rectum suggesting that lesions other than SSA/P may serve as the precursor for the majority of early-onset CRC.
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spelling pubmed-53957762017-04-20 Findings in young adults at colonoscopy from a hospital service database audit Wong, Stephanie Lidums, Ilmars Rosty, Christophe Ruszkiewicz, Andrew Parry, Susan Win, Aung Ko Tomita, Yoko Vatandoust, Sina Townsend, Amanda Patel, Dainik Hardingham, Jennifer E. Roder, David Smith, Eric Drew, Paul Marker, Julie Uylaki, Wendy Hewett, Peter Worthley, Daniel L. Symonds, Erin Young, Graeme P. Price, Timothy J. Young, Joanne P. BMC Gastroenterol Research Article BACKGROUND: Colorectal cancer (CRC) diagnosed at <50 years is predominantly located in the distal colon and rectum. Little is known about which lesion subtypes may serve as CRC precursors in young adults. The aim of this work was to document the prevalence and histological subtype of lesions seen in patients aged <50 years, and any associated clinical features. METHODS: An audit of the colonoscopy database at The Queen Elizabeth Hospital in Adelaide, South Australia over a 12-month period was undertaken. Findings were recorded from both colonoscopy reports and corresponding histological examination of excised lesions. RESULTS: Data were extracted from colonoscopies in 2064 patients. Those aged <50 comprised 485 (24%) of the total. CRC precursor lesions (including sessile serrated adenoma/polyps (SSA/P), traditional serrated adenomas, tubular adenomas ≥10 mm or with high-grade dysplasia, and conventional adenomas with villous histology) were seen in 4.3% of patients aged <50 and 12.9% of patients aged ≥50 (P <0.001). Among colonoscopies yielding CRC precursor lesions in patients under 50 years, SSA/P occurred in 52% of procedures (11/21), compared with 27% (55/204) of procedures in patients aged 50 and older (P = 0.02). SSA/P were proximally located in (10/11) 90% of patients aged under 50, and 80% (43/54) of those aged 50 and older (P = 0.46). CONCLUSIONS: SSA/P were the most frequently observed CRC precursor lesions in patients aged <50. Most CRCs in this age group are known to arise in the distal colon and rectum suggesting that lesions other than SSA/P may serve as the precursor for the majority of early-onset CRC. BioMed Central 2017-04-19 /pmc/articles/PMC5395776/ /pubmed/28424049 http://dx.doi.org/10.1186/s12876-017-0612-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Wong, Stephanie
Lidums, Ilmars
Rosty, Christophe
Ruszkiewicz, Andrew
Parry, Susan
Win, Aung Ko
Tomita, Yoko
Vatandoust, Sina
Townsend, Amanda
Patel, Dainik
Hardingham, Jennifer E.
Roder, David
Smith, Eric
Drew, Paul
Marker, Julie
Uylaki, Wendy
Hewett, Peter
Worthley, Daniel L.
Symonds, Erin
Young, Graeme P.
Price, Timothy J.
Young, Joanne P.
Findings in young adults at colonoscopy from a hospital service database audit
title Findings in young adults at colonoscopy from a hospital service database audit
title_full Findings in young adults at colonoscopy from a hospital service database audit
title_fullStr Findings in young adults at colonoscopy from a hospital service database audit
title_full_unstemmed Findings in young adults at colonoscopy from a hospital service database audit
title_short Findings in young adults at colonoscopy from a hospital service database audit
title_sort findings in young adults at colonoscopy from a hospital service database audit
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395776/
https://www.ncbi.nlm.nih.gov/pubmed/28424049
http://dx.doi.org/10.1186/s12876-017-0612-y
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