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Anti-MOG antibody-positive ADEM following infectious mononucleosis due to a primary EBV infection: a case report
BACKGROUND: Anti-Myelin oligodendrocyte glycoprotein (MOG) antibodies are detected in various demyelinating diseases, such as pediatric acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, and aquaporin-4 antibody-seronegative neuromyelitis optica spectrum disorder. We present a pa...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395865/ https://www.ncbi.nlm.nih.gov/pubmed/28420330 http://dx.doi.org/10.1186/s12883-017-0858-6 |
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author | Nakamura, Yoshitsugu Nakajima, Hideto Tani, Hiroki Hosokawa, Takafumi Ishida, Shimon Kimura, Fumiharu Kaneko, Kimihiko Takahashi, Toshiyuki Nakashima, Ichiro |
author_facet | Nakamura, Yoshitsugu Nakajima, Hideto Tani, Hiroki Hosokawa, Takafumi Ishida, Shimon Kimura, Fumiharu Kaneko, Kimihiko Takahashi, Toshiyuki Nakashima, Ichiro |
author_sort | Nakamura, Yoshitsugu |
collection | PubMed |
description | BACKGROUND: Anti-Myelin oligodendrocyte glycoprotein (MOG) antibodies are detected in various demyelinating diseases, such as pediatric acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, and aquaporin-4 antibody-seronegative neuromyelitis optica spectrum disorder. We present a patient who developed anti-MOG antibody-positive ADEM following infectious mononucleosis (IM) due to Epstein–Barr virus (EBV) infection. CASE PRESENTATION: A 36-year-old healthy man developed paresthesia of bilateral lower extremities and urinary retention 8 days after the onset of IM due to primary EBV infection. The MRI revealed the lesions in the cervical spinal cord, the conus medullaris, and the internal capsule. An examination of the cerebrospinal fluid revealed pleocytosis. Cell-based immunoassays revealed positivity for anti-MOG antibody with a titer of 1:1024 and negativity for anti-aquaporin-4 antibody. His symptoms quickly improved after steroid pulse therapy followed by oral betamethasone. Anti-MOG antibody titer at the 6-month follow-up was negative. CONCLUSIONS: This case suggests that primary EBV infection would trigger anti-MOG antibody-positive ADEM. Adult ADEM patients can be positive for anti-MOG antibody, the titers of which correlate well with the neurological symptoms. |
format | Online Article Text |
id | pubmed-5395865 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-53958652017-04-20 Anti-MOG antibody-positive ADEM following infectious mononucleosis due to a primary EBV infection: a case report Nakamura, Yoshitsugu Nakajima, Hideto Tani, Hiroki Hosokawa, Takafumi Ishida, Shimon Kimura, Fumiharu Kaneko, Kimihiko Takahashi, Toshiyuki Nakashima, Ichiro BMC Neurol Case Report BACKGROUND: Anti-Myelin oligodendrocyte glycoprotein (MOG) antibodies are detected in various demyelinating diseases, such as pediatric acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, and aquaporin-4 antibody-seronegative neuromyelitis optica spectrum disorder. We present a patient who developed anti-MOG antibody-positive ADEM following infectious mononucleosis (IM) due to Epstein–Barr virus (EBV) infection. CASE PRESENTATION: A 36-year-old healthy man developed paresthesia of bilateral lower extremities and urinary retention 8 days after the onset of IM due to primary EBV infection. The MRI revealed the lesions in the cervical spinal cord, the conus medullaris, and the internal capsule. An examination of the cerebrospinal fluid revealed pleocytosis. Cell-based immunoassays revealed positivity for anti-MOG antibody with a titer of 1:1024 and negativity for anti-aquaporin-4 antibody. His symptoms quickly improved after steroid pulse therapy followed by oral betamethasone. Anti-MOG antibody titer at the 6-month follow-up was negative. CONCLUSIONS: This case suggests that primary EBV infection would trigger anti-MOG antibody-positive ADEM. Adult ADEM patients can be positive for anti-MOG antibody, the titers of which correlate well with the neurological symptoms. BioMed Central 2017-04-19 /pmc/articles/PMC5395865/ /pubmed/28420330 http://dx.doi.org/10.1186/s12883-017-0858-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Nakamura, Yoshitsugu Nakajima, Hideto Tani, Hiroki Hosokawa, Takafumi Ishida, Shimon Kimura, Fumiharu Kaneko, Kimihiko Takahashi, Toshiyuki Nakashima, Ichiro Anti-MOG antibody-positive ADEM following infectious mononucleosis due to a primary EBV infection: a case report |
title | Anti-MOG antibody-positive ADEM following infectious mononucleosis due to a primary EBV infection: a case report |
title_full | Anti-MOG antibody-positive ADEM following infectious mononucleosis due to a primary EBV infection: a case report |
title_fullStr | Anti-MOG antibody-positive ADEM following infectious mononucleosis due to a primary EBV infection: a case report |
title_full_unstemmed | Anti-MOG antibody-positive ADEM following infectious mononucleosis due to a primary EBV infection: a case report |
title_short | Anti-MOG antibody-positive ADEM following infectious mononucleosis due to a primary EBV infection: a case report |
title_sort | anti-mog antibody-positive adem following infectious mononucleosis due to a primary ebv infection: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395865/ https://www.ncbi.nlm.nih.gov/pubmed/28420330 http://dx.doi.org/10.1186/s12883-017-0858-6 |
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