Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody

PglK is an ABC transporter that flips a lipid-linked oligosaccharide (LLO) that serves as a donor in protein N-glycosylation. Previous structures revealed two inward-facing conformations, both with very large separations of the nucleotide binding domains (NBDs), and a closed, ADP-bound state that fe...

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Detalles Bibliográficos
Autores principales: Perez, Camilo, Köhler, Martin, Janser, Daniel, Pardon, Els, Steyaert, Jan, Zenobi, Renato, Locher, Kaspar P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395944/
https://www.ncbi.nlm.nih.gov/pubmed/28422165
http://dx.doi.org/10.1038/srep46641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395944/
https://www.ncbi.nlm.nih.gov/pubmed/28422165
http://dx.doi.org/10.1038/srep46641

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