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On admission serum sodium and uric acid levels predict 30 day rehospitalization or death in patients with acute decompensated heart failure

AIMS: A considerable proportion of hospitalized patients for acute decompensated heart failure will be readmitted or die in short‐term follow‐up. In the present study, we aimed to assess the role of admission sodium (Na) and uric acid (UA) levels in the prediction of 30 day post‐discharge heart fail...

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Autores principales: Amin, Ahmad, Chitsazan, Mitra, Shiukhi Ahmad Abad, Fatemeh, Taghavi, Sepideh, Naderi, Nasim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396033/
https://www.ncbi.nlm.nih.gov/pubmed/28451453
http://dx.doi.org/10.1002/ehf2.12135
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author Amin, Ahmad
Chitsazan, Mitra
Shiukhi Ahmad Abad, Fatemeh
Taghavi, Sepideh
Naderi, Nasim
author_facet Amin, Ahmad
Chitsazan, Mitra
Shiukhi Ahmad Abad, Fatemeh
Taghavi, Sepideh
Naderi, Nasim
author_sort Amin, Ahmad
collection PubMed
description AIMS: A considerable proportion of hospitalized patients for acute decompensated heart failure will be readmitted or die in short‐term follow‐up. In the present study, we aimed to assess the role of admission sodium (Na) and uric acid (UA) levels in the prediction of 30 day post‐discharge heart failure readmission or all‐cause mortality in advanced heart failure patients admitted with acute decompensation. METHODS AND RESULTS: One hundred and forty consecutive advanced heart failure patients who were admitted for a recent cardiac decompensation were enrolled in this prospective study. Serum Na and UA levels remained statistically unchanged during index admission (P = 0. 54 and 0.19, respectively). Within 30 days post‐discharge, composite end point of heart failure rehospitalization or all‐cause death occurred in 62 (44.3%) patients (event group). Length of stay was statistically similar between patients in the event and non‐event groups (P = 0.38). No correlations were also found between length of stay and left ventricular ejection fraction, serum Na, UA, erythrocyte sedimentation rate (ESR), high‐sensitivity C‐reactive protein (hs‐CRP), creatinine, and N‐terminal pro b‐type natriuretic peptide (NT‐proBNP) levels (all P > 0.05). Lower left ventricular ejection fraction and Na and higher UA on admission were significantly associated with 30 day event both in univariate and multivariate analyses. CONCLUSIONS: Given the predictive role of baseline Na and UA for early post‐discharge outcome and the absence of significant changes in their levels during initial hospitalization, admission Na and UA can be considered as prognosticators of acute decompensated heart failure, which their prognostic significance cannot be affected by routine acute heart failure therapy.
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spelling pubmed-53960332017-04-25 On admission serum sodium and uric acid levels predict 30 day rehospitalization or death in patients with acute decompensated heart failure Amin, Ahmad Chitsazan, Mitra Shiukhi Ahmad Abad, Fatemeh Taghavi, Sepideh Naderi, Nasim ESC Heart Fail Original Research Articles AIMS: A considerable proportion of hospitalized patients for acute decompensated heart failure will be readmitted or die in short‐term follow‐up. In the present study, we aimed to assess the role of admission sodium (Na) and uric acid (UA) levels in the prediction of 30 day post‐discharge heart failure readmission or all‐cause mortality in advanced heart failure patients admitted with acute decompensation. METHODS AND RESULTS: One hundred and forty consecutive advanced heart failure patients who were admitted for a recent cardiac decompensation were enrolled in this prospective study. Serum Na and UA levels remained statistically unchanged during index admission (P = 0. 54 and 0.19, respectively). Within 30 days post‐discharge, composite end point of heart failure rehospitalization or all‐cause death occurred in 62 (44.3%) patients (event group). Length of stay was statistically similar between patients in the event and non‐event groups (P = 0.38). No correlations were also found between length of stay and left ventricular ejection fraction, serum Na, UA, erythrocyte sedimentation rate (ESR), high‐sensitivity C‐reactive protein (hs‐CRP), creatinine, and N‐terminal pro b‐type natriuretic peptide (NT‐proBNP) levels (all P > 0.05). Lower left ventricular ejection fraction and Na and higher UA on admission were significantly associated with 30 day event both in univariate and multivariate analyses. CONCLUSIONS: Given the predictive role of baseline Na and UA for early post‐discharge outcome and the absence of significant changes in their levels during initial hospitalization, admission Na and UA can be considered as prognosticators of acute decompensated heart failure, which their prognostic significance cannot be affected by routine acute heart failure therapy. John Wiley and Sons Inc. 2017-02-17 /pmc/articles/PMC5396033/ /pubmed/28451453 http://dx.doi.org/10.1002/ehf2.12135 Text en © 2017 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research Articles
Amin, Ahmad
Chitsazan, Mitra
Shiukhi Ahmad Abad, Fatemeh
Taghavi, Sepideh
Naderi, Nasim
On admission serum sodium and uric acid levels predict 30 day rehospitalization or death in patients with acute decompensated heart failure
title On admission serum sodium and uric acid levels predict 30 day rehospitalization or death in patients with acute decompensated heart failure
title_full On admission serum sodium and uric acid levels predict 30 day rehospitalization or death in patients with acute decompensated heart failure
title_fullStr On admission serum sodium and uric acid levels predict 30 day rehospitalization or death in patients with acute decompensated heart failure
title_full_unstemmed On admission serum sodium and uric acid levels predict 30 day rehospitalization or death in patients with acute decompensated heart failure
title_short On admission serum sodium and uric acid levels predict 30 day rehospitalization or death in patients with acute decompensated heart failure
title_sort on admission serum sodium and uric acid levels predict 30 day rehospitalization or death in patients with acute decompensated heart failure
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396033/
https://www.ncbi.nlm.nih.gov/pubmed/28451453
http://dx.doi.org/10.1002/ehf2.12135
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