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Serum albumin level and hospital mortality in acute non‐ischemic heart failure
AIMS: Hypoalbuminemia is common in heart failure (HF), especially in elderly patients. It is associated with an increased risk of death. The present study sought to examine the prognostic significance of serum albumin level in the prediction of hospital mortality in patients admitted for acute non‐i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396050/ https://www.ncbi.nlm.nih.gov/pubmed/28451450 http://dx.doi.org/10.1002/ehf2.12128 |
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author | Ancion, Arnaud Allepaerts, Sophie Oury, Cécile Gori, Anne‐Stephan Piérard, Luc A. Lancellotti, Patrizio |
author_facet | Ancion, Arnaud Allepaerts, Sophie Oury, Cécile Gori, Anne‐Stephan Piérard, Luc A. Lancellotti, Patrizio |
author_sort | Ancion, Arnaud |
collection | PubMed |
description | AIMS: Hypoalbuminemia is common in heart failure (HF), especially in elderly patients. It is associated with an increased risk of death. The present study sought to examine the prognostic significance of serum albumin level in the prediction of hospital mortality in patients admitted for acute non‐ischemic HF. METHODS AND RESULTS: We examined the association between albumin and hospital mortality in a cohort of 546 patients admitted for acute non‐ischemic HF. None of the patients had infectious disease, severe arrhythmias (atrial fibrillation, ventricular tachycardia, ventricular fibrillation), required invasive ventilation, or presented with acute coronary syndrome or primary valvular disease. Thirty‐six patients (7%) died during the hospital stay. These patients were significantly older (78 ± 9 vs. 72 ± 12 years; P = 0.006), had higher heart rate (P < 0.0001), increased creatinine level (P = 0.01), lower systolic and diastolic blood pressures (P < 0.05), elevated leucocyte count (P = 0.001), and lower albumin levels (31.3 ± 5.6 g/L vs. 36.9 ± 4.1 g/L; P < 0.001). With multivariable analysis, age (P = 0.01), heart rate (P < 0.0003), diastolic blood pressure (P < 0.01), leukocyte count (P = 0.009), and serum albumin level (P < 0.0001) emerged as independent predictors of hospital mortality. Hypoalbuminemia (<34 g/L) yielded the best sensitivity (78.8%) and specificity (75%) for predicting hospital death. CONCLUSIONS: Serum albumin level measured at admission can serve as a simple prognostic factor in acute non‐ischemic HF. Hypoalbuminemia is associated with increased risk of hospital mortality, especially in elderly patients. |
format | Online Article Text |
id | pubmed-5396050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-53960502017-04-25 Serum albumin level and hospital mortality in acute non‐ischemic heart failure Ancion, Arnaud Allepaerts, Sophie Oury, Cécile Gori, Anne‐Stephan Piérard, Luc A. Lancellotti, Patrizio ESC Heart Fail Original Research Articles AIMS: Hypoalbuminemia is common in heart failure (HF), especially in elderly patients. It is associated with an increased risk of death. The present study sought to examine the prognostic significance of serum albumin level in the prediction of hospital mortality in patients admitted for acute non‐ischemic HF. METHODS AND RESULTS: We examined the association between albumin and hospital mortality in a cohort of 546 patients admitted for acute non‐ischemic HF. None of the patients had infectious disease, severe arrhythmias (atrial fibrillation, ventricular tachycardia, ventricular fibrillation), required invasive ventilation, or presented with acute coronary syndrome or primary valvular disease. Thirty‐six patients (7%) died during the hospital stay. These patients were significantly older (78 ± 9 vs. 72 ± 12 years; P = 0.006), had higher heart rate (P < 0.0001), increased creatinine level (P = 0.01), lower systolic and diastolic blood pressures (P < 0.05), elevated leucocyte count (P = 0.001), and lower albumin levels (31.3 ± 5.6 g/L vs. 36.9 ± 4.1 g/L; P < 0.001). With multivariable analysis, age (P = 0.01), heart rate (P < 0.0003), diastolic blood pressure (P < 0.01), leukocyte count (P = 0.009), and serum albumin level (P < 0.0001) emerged as independent predictors of hospital mortality. Hypoalbuminemia (<34 g/L) yielded the best sensitivity (78.8%) and specificity (75%) for predicting hospital death. CONCLUSIONS: Serum albumin level measured at admission can serve as a simple prognostic factor in acute non‐ischemic HF. Hypoalbuminemia is associated with increased risk of hospital mortality, especially in elderly patients. John Wiley and Sons Inc. 2017-01-13 /pmc/articles/PMC5396050/ /pubmed/28451450 http://dx.doi.org/10.1002/ehf2.12128 Text en © 2017 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Research Articles Ancion, Arnaud Allepaerts, Sophie Oury, Cécile Gori, Anne‐Stephan Piérard, Luc A. Lancellotti, Patrizio Serum albumin level and hospital mortality in acute non‐ischemic heart failure |
title | Serum albumin level and hospital mortality in acute non‐ischemic heart failure |
title_full | Serum albumin level and hospital mortality in acute non‐ischemic heart failure |
title_fullStr | Serum albumin level and hospital mortality in acute non‐ischemic heart failure |
title_full_unstemmed | Serum albumin level and hospital mortality in acute non‐ischemic heart failure |
title_short | Serum albumin level and hospital mortality in acute non‐ischemic heart failure |
title_sort | serum albumin level and hospital mortality in acute non‐ischemic heart failure |
topic | Original Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396050/ https://www.ncbi.nlm.nih.gov/pubmed/28451450 http://dx.doi.org/10.1002/ehf2.12128 |
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