Antiprotozoal Nitazoxanide Derivatives: Synthesis, Bioassays and QSAR Study Combined with Docking for Mechanistic Insight

In view of the serious health problems concerning infectious diseases in heavily populated areas, we followed the strategy of lead compound diversification to evaluate the near-by chemical space for new organic compounds. To this end, twenty derivatives of nitazoxanide (NTZ) were synthesized and tes...

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Detalles Bibliográficos
Autores principales: Scior, Thomas, Lozano-Aponte, Jorge, Ajmani, Subhash, Hernández-Montero, Eduardo, Chávez-Silva, Fabiola, Hernández-Núñez, Emanuel, Moo-Puc, Rosa, Fraguela-Collar, Andres, Navarrete-Vázquez, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396257/
https://www.ncbi.nlm.nih.gov/pubmed/25872791
http://dx.doi.org/10.2174/1573409911666150414145937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396257/
https://www.ncbi.nlm.nih.gov/pubmed/25872791
http://dx.doi.org/10.2174/1573409911666150414145937

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