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(19)F‐NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo‐β‐Lactamase

Resistance to β‐lactam antibiotics mediated by metallo‐β‐lactamases (MBLs) is a growing problem. We describe the use of protein‐observe (19)F‐NMR (PrOF NMR) to study the dynamics of the São Paulo MBL (SPM‐1) from β‐lactam‐resistant Pseudomonas aeruginosa. Cysteinyl variants on the α3 and L3 regions,...

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Detalles Bibliográficos
Autores principales:	Abboud, Martine I., Hinchliffe, Philip, Brem, Jürgen, Macsics, Robert, Pfeffer, Inga, Makena, Anne, Umland, Klaus‐Daniel, Rydzik, Anna M., Li, Guo‐Bo, Spencer, James, Claridge, Timothy D. W., Schofield, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396265/ https://www.ncbi.nlm.nih.gov/pubmed/28252254 http://dx.doi.org/10.1002/anie.201612185

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