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Microbial elements as the initial triggers in the pathogenesis of polymorphic light eruption?

The primary trigger of polymorphic light eruption (PLE) remains to be uncovered. We hypothesize that PLE may be initiated by elements resulting from UV‐induced damage to microbial communities of the skin, leading to a cascade of events eventually resulting in the skin rash of the disease. One mechan...

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Autores principales: Patra, VijayKumar, Wolf, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396279/
https://www.ncbi.nlm.nih.gov/pubmed/27514020
http://dx.doi.org/10.1111/exd.13162
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author Patra, VijayKumar
Wolf, Peter
author_facet Patra, VijayKumar
Wolf, Peter
author_sort Patra, VijayKumar
collection PubMed
description The primary trigger of polymorphic light eruption (PLE) remains to be uncovered. We hypothesize that PLE may be initiated by elements resulting from UV‐induced damage to microbial communities of the skin, leading to a cascade of events eventually resulting in the skin rash of the disease. One mechanism by which epidermal injury by UV radiation could trigger PLE are danger signals such as damage or pathogen associated molecular patterns DAMP/PAMPs or commensal‐associated molecular patterns (CAMPs). Such triggers could be produced due to UV‐induced stress on microbial communities of the skin and exacerbate inflammatory responses by inducing the innate immune system through antimicrobial peptides (AMPs) such as psoriasin, RNase7, HBD‐2 and LL‐37. These AMPs also actively take part in initiating adaptive immunity. That signals derived from microbial rather than human elements may initiate PLE is supported by series of observations, including the PLE‐protective effect of topically applied microbial‐derived DNA repair enzymes.
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spelling pubmed-53962792017-04-25 Microbial elements as the initial triggers in the pathogenesis of polymorphic light eruption? Patra, VijayKumar Wolf, Peter Exp Dermatol Hypothesis Letter The primary trigger of polymorphic light eruption (PLE) remains to be uncovered. We hypothesize that PLE may be initiated by elements resulting from UV‐induced damage to microbial communities of the skin, leading to a cascade of events eventually resulting in the skin rash of the disease. One mechanism by which epidermal injury by UV radiation could trigger PLE are danger signals such as damage or pathogen associated molecular patterns DAMP/PAMPs or commensal‐associated molecular patterns (CAMPs). Such triggers could be produced due to UV‐induced stress on microbial communities of the skin and exacerbate inflammatory responses by inducing the innate immune system through antimicrobial peptides (AMPs) such as psoriasin, RNase7, HBD‐2 and LL‐37. These AMPs also actively take part in initiating adaptive immunity. That signals derived from microbial rather than human elements may initiate PLE is supported by series of observations, including the PLE‐protective effect of topically applied microbial‐derived DNA repair enzymes. John Wiley and Sons Inc. 2016-11-29 2016-12 /pmc/articles/PMC5396279/ /pubmed/27514020 http://dx.doi.org/10.1111/exd.13162 Text en © 2016 The Authors Experimental Dermatology Published by John Wiley & Sons Ltd This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Hypothesis Letter
Patra, VijayKumar
Wolf, Peter
Microbial elements as the initial triggers in the pathogenesis of polymorphic light eruption?
title Microbial elements as the initial triggers in the pathogenesis of polymorphic light eruption?
title_full Microbial elements as the initial triggers in the pathogenesis of polymorphic light eruption?
title_fullStr Microbial elements as the initial triggers in the pathogenesis of polymorphic light eruption?
title_full_unstemmed Microbial elements as the initial triggers in the pathogenesis of polymorphic light eruption?
title_short Microbial elements as the initial triggers in the pathogenesis of polymorphic light eruption?
title_sort microbial elements as the initial triggers in the pathogenesis of polymorphic light eruption?
topic Hypothesis Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396279/
https://www.ncbi.nlm.nih.gov/pubmed/27514020
http://dx.doi.org/10.1111/exd.13162
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