Multiple myeloma: routes to diagnosis, clinical characteristics and survival – findings from a UK population‐based study

Prompt cancer diagnosis may align UK survival with European averages. We examined the impact of route to diagnosis on survival for multiple myeloma patients diagnosed 2012–2013 using data from our population‐based patient cohort that links to national death notifications and collects details on trea...

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Autores principales: Howell, Debra, Smith, Alexandra, Appleton, Simon, Bagguley, Timothy, Macleod, Una, Cook, Gordon, Patmore, Russell, Roman, Eve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Haematological Malignancy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396308/
https://www.ncbi.nlm.nih.gov/pubmed/28146275
http://dx.doi.org/10.1111/bjh.14513
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author Howell, Debra
Smith, Alexandra
Appleton, Simon
Bagguley, Timothy
Macleod, Una
Cook, Gordon
Patmore, Russell
Roman, Eve
author_facet Howell, Debra
Smith, Alexandra
Appleton, Simon
Bagguley, Timothy
Macleod, Una
Cook, Gordon
Patmore, Russell
Roman, Eve
author_sort Howell, Debra
collection PubMed
description Prompt cancer diagnosis may align UK survival with European averages. We examined the impact of route to diagnosis on survival for multiple myeloma patients diagnosed 2012–2013 using data from our population‐based patient cohort that links to national death notifications and collects details on treatment and response (n = 441). Emergency presentation was associated with advanced disease and poorer outcomes, and was the commonest route to diagnosis (28·1%) followed by General Practitioner urgent (19·0%) and two‐week wait (17·2%) referrals. CRAB (elevated Calcium, Renal failure, Anaemia, Bone lesions) distribution varied by route (P < 0·001), with patients with emergency presentations most likely to have ≥2 features and significantly worse survival (log‐rank test χ(2) = 13·8, P = 0·0002).
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spelling pubmed-53963082017-04-25 Multiple myeloma: routes to diagnosis, clinical characteristics and survival – findings from a UK population‐based study Howell, Debra Smith, Alexandra Appleton, Simon Bagguley, Timothy Macleod, Una Cook, Gordon Patmore, Russell Roman, Eve Br J Haematol Haematological Malignancy Prompt cancer diagnosis may align UK survival with European averages. We examined the impact of route to diagnosis on survival for multiple myeloma patients diagnosed 2012–2013 using data from our population‐based patient cohort that links to national death notifications and collects details on treatment and response (n = 441). Emergency presentation was associated with advanced disease and poorer outcomes, and was the commonest route to diagnosis (28·1%) followed by General Practitioner urgent (19·0%) and two‐week wait (17·2%) referrals. CRAB (elevated Calcium, Renal failure, Anaemia, Bone lesions) distribution varied by route (P < 0·001), with patients with emergency presentations most likely to have ≥2 features and significantly worse survival (log‐rank test χ(2) = 13·8, P = 0·0002). John Wiley and Sons Inc. 2017-02-01 2017-04 /pmc/articles/PMC5396308/ /pubmed/28146275 http://dx.doi.org/10.1111/bjh.14513 Text en © 2017 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Haematological Malignancy
Howell, Debra
Smith, Alexandra
Appleton, Simon
Bagguley, Timothy
Macleod, Una
Cook, Gordon
Patmore, Russell
Roman, Eve
Multiple myeloma: routes to diagnosis, clinical characteristics and survival – findings from a UK population‐based study
title Multiple myeloma: routes to diagnosis, clinical characteristics and survival – findings from a UK population‐based study
title_full Multiple myeloma: routes to diagnosis, clinical characteristics and survival – findings from a UK population‐based study
title_fullStr Multiple myeloma: routes to diagnosis, clinical characteristics and survival – findings from a UK population‐based study
title_full_unstemmed Multiple myeloma: routes to diagnosis, clinical characteristics and survival – findings from a UK population‐based study
title_short Multiple myeloma: routes to diagnosis, clinical characteristics and survival – findings from a UK population‐based study
title_sort multiple myeloma: routes to diagnosis, clinical characteristics and survival – findings from a uk population‐based study
topic Haematological Malignancy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396308/
https://www.ncbi.nlm.nih.gov/pubmed/28146275
http://dx.doi.org/10.1111/bjh.14513
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