Regioselective Enzymatic Carboxylation of Bioactive (Poly)phenols

In order to extend the applicability of the regioselective enzymatic carboxylation of phenols, the substrate scope of o‐benzoic acid (de)carboxylases has been investigated towards complex molecules with an emphasis on flavouring agents and polyphenols possessing antioxidant properties. o‐Hydroxycarb...

Descripción completa

Detalles Bibliográficos
Autores principales: Plasch, Katharina, Resch, Verena, Hitce, Julien, Popłoński, Jarosław, Faber, Kurt, Glueck, Silvia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396361/
https://www.ncbi.nlm.nih.gov/pubmed/28450825
http://dx.doi.org/10.1002/adsc.201601046
Descripción
Sumario:In order to extend the applicability of the regioselective enzymatic carboxylation of phenols, the substrate scope of o‐benzoic acid (de)carboxylases has been investigated towards complex molecules with an emphasis on flavouring agents and polyphenols possessing antioxidant properties. o‐Hydroxycarboxylic acid products were obtained with perfect regioselectivity, in moderate to excellent yields. The applicability of this method was proven by the regioselective bio‐carboxylation of resveratrol on a preparative scale with 95% yield. [Image: see text]

Ejemplares similares