Regioselective Enzymatic Carboxylation of Bioactive (Poly)phenols

In order to extend the applicability of the regioselective enzymatic carboxylation of phenols, the substrate scope of o‐benzoic acid (de)carboxylases has been investigated towards complex molecules with an emphasis on flavouring agents and polyphenols possessing antioxidant properties. o‐Hydroxycarb...

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Detalles Bibliográficos
Autores principales: Plasch, Katharina, Resch, Verena, Hitce, Julien, Popłoński, Jarosław, Faber, Kurt, Glueck, Silvia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396361/
https://www.ncbi.nlm.nih.gov/pubmed/28450825
http://dx.doi.org/10.1002/adsc.201601046
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author Plasch, Katharina
Resch, Verena
Hitce, Julien
Popłoński, Jarosław
Faber, Kurt
Glueck, Silvia M.
author_facet Plasch, Katharina
Resch, Verena
Hitce, Julien
Popłoński, Jarosław
Faber, Kurt
Glueck, Silvia M.
author_sort Plasch, Katharina
collection PubMed
description In order to extend the applicability of the regioselective enzymatic carboxylation of phenols, the substrate scope of o‐benzoic acid (de)carboxylases has been investigated towards complex molecules with an emphasis on flavouring agents and polyphenols possessing antioxidant properties. o‐Hydroxycarboxylic acid products were obtained with perfect regioselectivity, in moderate to excellent yields. The applicability of this method was proven by the regioselective bio‐carboxylation of resveratrol on a preparative scale with 95% yield. [Image: see text]
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spelling pubmed-53963612017-04-25 Regioselective Enzymatic Carboxylation of Bioactive (Poly)phenols Plasch, Katharina Resch, Verena Hitce, Julien Popłoński, Jarosław Faber, Kurt Glueck, Silvia M. Adv Synth Catal Communications In order to extend the applicability of the regioselective enzymatic carboxylation of phenols, the substrate scope of o‐benzoic acid (de)carboxylases has been investigated towards complex molecules with an emphasis on flavouring agents and polyphenols possessing antioxidant properties. o‐Hydroxycarboxylic acid products were obtained with perfect regioselectivity, in moderate to excellent yields. The applicability of this method was proven by the regioselective bio‐carboxylation of resveratrol on a preparative scale with 95% yield. [Image: see text] John Wiley and Sons Inc. 2017-01-18 2017-03-20 /pmc/articles/PMC5396361/ /pubmed/28450825 http://dx.doi.org/10.1002/adsc.201601046 Text en © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Plasch, Katharina
Resch, Verena
Hitce, Julien
Popłoński, Jarosław
Faber, Kurt
Glueck, Silvia M.
Regioselective Enzymatic Carboxylation of Bioactive (Poly)phenols
title Regioselective Enzymatic Carboxylation of Bioactive (Poly)phenols
title_full Regioselective Enzymatic Carboxylation of Bioactive (Poly)phenols
title_fullStr Regioselective Enzymatic Carboxylation of Bioactive (Poly)phenols
title_full_unstemmed Regioselective Enzymatic Carboxylation of Bioactive (Poly)phenols
title_short Regioselective Enzymatic Carboxylation of Bioactive (Poly)phenols
title_sort regioselective enzymatic carboxylation of bioactive (poly)phenols
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396361/
https://www.ncbi.nlm.nih.gov/pubmed/28450825
http://dx.doi.org/10.1002/adsc.201601046
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AT popłonskijarosław regioselectiveenzymaticcarboxylationofbioactivepolyphenols
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