A Cu‐Catalysed Radical Cross‐Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles

The synthesis of acridanes and related compounds through a Cu‐catalysed radical cross‐dehydrogenative coupling of simple 2‐[2‐(arylamino)aryl]malonates is reported. This method can be further streamlined to a one‐pot protocol involving the in situ fomation of the 2‐[2‐(arylamino)aryl]malonate by α‐a...

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Detalles Bibliográficos
Autores principales: Hurst, Timothy E., Taylor, Richard J. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396374/
https://www.ncbi.nlm.nih.gov/pubmed/28479872
http://dx.doi.org/10.1002/ejoc.201601336
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author Hurst, Timothy E.
Taylor, Richard J. K.
author_facet Hurst, Timothy E.
Taylor, Richard J. K.
author_sort Hurst, Timothy E.
collection PubMed
description The synthesis of acridanes and related compounds through a Cu‐catalysed radical cross‐dehydrogenative coupling of simple 2‐[2‐(arylamino)aryl]malonates is reported. This method can be further streamlined to a one‐pot protocol involving the in situ fomation of the 2‐[2‐(arylamino)aryl]malonate by α‐arylation of diethyl malonate with 2‐bromodiarylamines under Pd catalysis, followed by Cu‐catalysed cyclisation.
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spelling pubmed-53963742017-05-04 A Cu‐Catalysed Radical Cross‐Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles Hurst, Timothy E. Taylor, Richard J. K. European J Org Chem Communications The synthesis of acridanes and related compounds through a Cu‐catalysed radical cross‐dehydrogenative coupling of simple 2‐[2‐(arylamino)aryl]malonates is reported. This method can be further streamlined to a one‐pot protocol involving the in situ fomation of the 2‐[2‐(arylamino)aryl]malonate by α‐arylation of diethyl malonate with 2‐bromodiarylamines under Pd catalysis, followed by Cu‐catalysed cyclisation. John Wiley and Sons Inc. 2017-01-06 2017-01-03 /pmc/articles/PMC5396374/ /pubmed/28479872 http://dx.doi.org/10.1002/ejoc.201601336 Text en © 2017 The Authors. Published by Wiley‐VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Hurst, Timothy E.
Taylor, Richard J. K.
A Cu‐Catalysed Radical Cross‐Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles
title A Cu‐Catalysed Radical Cross‐Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles
title_full A Cu‐Catalysed Radical Cross‐Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles
title_fullStr A Cu‐Catalysed Radical Cross‐Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles
title_full_unstemmed A Cu‐Catalysed Radical Cross‐Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles
title_short A Cu‐Catalysed Radical Cross‐Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles
title_sort cu‐catalysed radical cross‐dehydrogenative coupling approach to acridanes and related heterocycles
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396374/
https://www.ncbi.nlm.nih.gov/pubmed/28479872
http://dx.doi.org/10.1002/ejoc.201601336
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