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Iridium-catalyzed asymmetric hydrogenation of racemic α-substituted lactones to chiral diols

We report a protocol for the highly efficient iridium-catalyzed asymmetric hydrogenation of racemic α-substituted lactones via dynamic kinetic resolution. Using Ir-SpiroPAP (R)-1d as a catalyst, a wide range of chiral diols were prepared in a high yield (80–95%) with a high enantioselectivity (up to...

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Detalles Bibliográficos
Autores principales:	Yang, Xiao-Hui, Yue, Hai-Tao, Yu, Na, Li, Yi-Pan, Xie, Jian-Hua, Zhou, Qi-Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396509/ https://www.ncbi.nlm.nih.gov/pubmed/28451302 http://dx.doi.org/10.1039/c6sc04609f

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