Topological length of white matter connections predicts their rate of atrophy in premanifest Huntington’s disease

We lack a mechanistic explanation for the stereotyped pattern of white matter loss seen in Huntington’s disease (HD). While the earliest white matter changes are seen around the striatum, within the corpus callosum, and in the posterior white matter tracts, the order in which these changes occur and...

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Detalles Bibliográficos
Autores principales: McColgan, Peter, Seunarine, Kiran K., Gregory, Sarah, Razi, Adeel, Papoutsi, Marina, Long, Jeffrey D., Mills, James A., Johnson, Eileanoir, Durr, Alexandra, Roos, Raymund A.C., Leavitt, Blair R., Stout, Julie C., Scahill, Rachael I., Clark, Chris A., Rees, Geraint, Tabrizi, Sarah J., Investigators, the Track-On HD
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396531/
https://www.ncbi.nlm.nih.gov/pubmed/28422761
http://dx.doi.org/10.1172/jci.insight.92641

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