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Near-IR-induced dissociation of thermally-sensitive star polymers
Responsive systems sensitive to near-infrared (NIR) light are promising for triggered release due to efficient deep tissue penetration of NIR irradiation relative to higher energy sources (e.g., UV), allowing for spatiotemporal control over triggering events with minimal potential for tissue damage....
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396554/ https://www.ncbi.nlm.nih.gov/pubmed/28451303 http://dx.doi.org/10.1039/c6sc04650a |
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author | Dai, Yuqiong Sun, Hao Pal, Sunirmal Zhang, Yunlu Park, Sangwoo Kabb, Christopher P. Wei, Wei David Sumerlin, Brent S. |
author_facet | Dai, Yuqiong Sun, Hao Pal, Sunirmal Zhang, Yunlu Park, Sangwoo Kabb, Christopher P. Wei, Wei David Sumerlin, Brent S. |
author_sort | Dai, Yuqiong |
collection | PubMed |
description | Responsive systems sensitive to near-infrared (NIR) light are promising for triggered release due to efficient deep tissue penetration of NIR irradiation relative to higher energy sources (e.g., UV), allowing for spatiotemporal control over triggering events with minimal potential for tissue damage. Herein, we report star polymers containing thermally-labile azo linkages that dissociate during conventional heating or during localized heating via the photothermal effect upon NIR irradiation. Controlled release during conventional heating was investigated for the star polymers loaded with a model dye, with negligible release being observed at 25 °C and >80% release at 90 °C. Star polymers co-loaded with NIR-responsive indocyanine green showed rapid dye release upon NIR irradiation (λ ≥ 715 nm) due to the photothermally-induced degradation of azo linkages within the cores of the star polymers. This approach provides access to a new class of delivery and release systems that can be triggered by noninvasive external stimulation. |
format | Online Article Text |
id | pubmed-5396554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-53965542017-04-27 Near-IR-induced dissociation of thermally-sensitive star polymers Dai, Yuqiong Sun, Hao Pal, Sunirmal Zhang, Yunlu Park, Sangwoo Kabb, Christopher P. Wei, Wei David Sumerlin, Brent S. Chem Sci Chemistry Responsive systems sensitive to near-infrared (NIR) light are promising for triggered release due to efficient deep tissue penetration of NIR irradiation relative to higher energy sources (e.g., UV), allowing for spatiotemporal control over triggering events with minimal potential for tissue damage. Herein, we report star polymers containing thermally-labile azo linkages that dissociate during conventional heating or during localized heating via the photothermal effect upon NIR irradiation. Controlled release during conventional heating was investigated for the star polymers loaded with a model dye, with negligible release being observed at 25 °C and >80% release at 90 °C. Star polymers co-loaded with NIR-responsive indocyanine green showed rapid dye release upon NIR irradiation (λ ≥ 715 nm) due to the photothermally-induced degradation of azo linkages within the cores of the star polymers. This approach provides access to a new class of delivery and release systems that can be triggered by noninvasive external stimulation. Royal Society of Chemistry 2017-03-01 2016-12-13 /pmc/articles/PMC5396554/ /pubmed/28451303 http://dx.doi.org/10.1039/c6sc04650a Text en This journal is © The Royal Society of Chemistry 2016 https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Chemistry Dai, Yuqiong Sun, Hao Pal, Sunirmal Zhang, Yunlu Park, Sangwoo Kabb, Christopher P. Wei, Wei David Sumerlin, Brent S. Near-IR-induced dissociation of thermally-sensitive star polymers |
title | Near-IR-induced dissociation of thermally-sensitive star polymers
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title_full | Near-IR-induced dissociation of thermally-sensitive star polymers
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title_fullStr | Near-IR-induced dissociation of thermally-sensitive star polymers
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title_full_unstemmed | Near-IR-induced dissociation of thermally-sensitive star polymers
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title_short | Near-IR-induced dissociation of thermally-sensitive star polymers
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title_sort | near-ir-induced dissociation of thermally-sensitive star polymers |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396554/ https://www.ncbi.nlm.nih.gov/pubmed/28451303 http://dx.doi.org/10.1039/c6sc04650a |
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