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Near-IR-induced dissociation of thermally-sensitive star polymers

Responsive systems sensitive to near-infrared (NIR) light are promising for triggered release due to efficient deep tissue penetration of NIR irradiation relative to higher energy sources (e.g., UV), allowing for spatiotemporal control over triggering events with minimal potential for tissue damage....

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Autores principales: Dai, Yuqiong, Sun, Hao, Pal, Sunirmal, Zhang, Yunlu, Park, Sangwoo, Kabb, Christopher P., Wei, Wei David, Sumerlin, Brent S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396554/
https://www.ncbi.nlm.nih.gov/pubmed/28451303
http://dx.doi.org/10.1039/c6sc04650a
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author Dai, Yuqiong
Sun, Hao
Pal, Sunirmal
Zhang, Yunlu
Park, Sangwoo
Kabb, Christopher P.
Wei, Wei David
Sumerlin, Brent S.
author_facet Dai, Yuqiong
Sun, Hao
Pal, Sunirmal
Zhang, Yunlu
Park, Sangwoo
Kabb, Christopher P.
Wei, Wei David
Sumerlin, Brent S.
author_sort Dai, Yuqiong
collection PubMed
description Responsive systems sensitive to near-infrared (NIR) light are promising for triggered release due to efficient deep tissue penetration of NIR irradiation relative to higher energy sources (e.g., UV), allowing for spatiotemporal control over triggering events with minimal potential for tissue damage. Herein, we report star polymers containing thermally-labile azo linkages that dissociate during conventional heating or during localized heating via the photothermal effect upon NIR irradiation. Controlled release during conventional heating was investigated for the star polymers loaded with a model dye, with negligible release being observed at 25 °C and >80% release at 90 °C. Star polymers co-loaded with NIR-responsive indocyanine green showed rapid dye release upon NIR irradiation (λ ≥ 715 nm) due to the photothermally-induced degradation of azo linkages within the cores of the star polymers. This approach provides access to a new class of delivery and release systems that can be triggered by noninvasive external stimulation.
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spelling pubmed-53965542017-04-27 Near-IR-induced dissociation of thermally-sensitive star polymers Dai, Yuqiong Sun, Hao Pal, Sunirmal Zhang, Yunlu Park, Sangwoo Kabb, Christopher P. Wei, Wei David Sumerlin, Brent S. Chem Sci Chemistry Responsive systems sensitive to near-infrared (NIR) light are promising for triggered release due to efficient deep tissue penetration of NIR irradiation relative to higher energy sources (e.g., UV), allowing for spatiotemporal control over triggering events with minimal potential for tissue damage. Herein, we report star polymers containing thermally-labile azo linkages that dissociate during conventional heating or during localized heating via the photothermal effect upon NIR irradiation. Controlled release during conventional heating was investigated for the star polymers loaded with a model dye, with negligible release being observed at 25 °C and >80% release at 90 °C. Star polymers co-loaded with NIR-responsive indocyanine green showed rapid dye release upon NIR irradiation (λ ≥ 715 nm) due to the photothermally-induced degradation of azo linkages within the cores of the star polymers. This approach provides access to a new class of delivery and release systems that can be triggered by noninvasive external stimulation. Royal Society of Chemistry 2017-03-01 2016-12-13 /pmc/articles/PMC5396554/ /pubmed/28451303 http://dx.doi.org/10.1039/c6sc04650a Text en This journal is © The Royal Society of Chemistry 2016 https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Dai, Yuqiong
Sun, Hao
Pal, Sunirmal
Zhang, Yunlu
Park, Sangwoo
Kabb, Christopher P.
Wei, Wei David
Sumerlin, Brent S.
Near-IR-induced dissociation of thermally-sensitive star polymers
title Near-IR-induced dissociation of thermally-sensitive star polymers
title_full Near-IR-induced dissociation of thermally-sensitive star polymers
title_fullStr Near-IR-induced dissociation of thermally-sensitive star polymers
title_full_unstemmed Near-IR-induced dissociation of thermally-sensitive star polymers
title_short Near-IR-induced dissociation of thermally-sensitive star polymers
title_sort near-ir-induced dissociation of thermally-sensitive star polymers
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396554/
https://www.ncbi.nlm.nih.gov/pubmed/28451303
http://dx.doi.org/10.1039/c6sc04650a
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