Cargando…
Adjusting the HIV prevalence for non‐respondents using mortality rates in an open cohort in northwest Tanzania
OBJECTIVE: To estimate HIV prevalence in adults who have not tested for HIV using age‐specific mortality rates and to adjust the overall population HIV prevalence to include both tested and untested adults. METHODS: An open cohort study was established since 1994 with demographic surveillance system...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396574/ https://www.ncbi.nlm.nih.gov/pubmed/24655037 http://dx.doi.org/10.1111/tmi.12304 |
_version_ | 1783230090975379456 |
---|---|
author | Tenu, Filemon Isingo, Raphael Zaba, Basia Urassa, Mark Todd, Jim |
author_facet | Tenu, Filemon Isingo, Raphael Zaba, Basia Urassa, Mark Todd, Jim |
author_sort | Tenu, Filemon |
collection | PubMed |
description | OBJECTIVE: To estimate HIV prevalence in adults who have not tested for HIV using age‐specific mortality rates and to adjust the overall population HIV prevalence to include both tested and untested adults. METHODS: An open cohort study was established since 1994 with demographic surveillance system (DSS) and five serological surveys conducted. Deaths from Kisesa DSS were used to estimate mortality rates and 95% confidence intervals by HIV status for 3‐ 5‐year periods (1995–1999, 2000–2004, and 2005–2009). Assuming that mortality rates in individuals who did not test for HIV are similar to those in tested individuals, and dependent on age, sex and HIV status and HIV, prevalence was estimated. RESULTS: In 1995–1999, mortality rates (per 1000 person years) were 43.7 (95% CI 35.7–53.4) for HIV positive, 2.6 (95% CI 2.1–3.2) in HIV negative and 16.4 (95% CI 14.4–18.7) in untested. In 2000–2004, mortality rates were 43.3 (95% CI 36.2–51.9) in HIV positive, 3.3 (95% CI 2.8–4.0) in HIV negative and 11.9 (95% CI 10.5–13.6) in untested. In 2005–2009, mortality rates were 30.7 (95% CI 24.8–38.0) in HIV positive, 4.1 (95% CI 3.5–4.9) in HIV negative and 5.7 (95% CI 5.0–6.6) in untested residents. In the three survey periods (1995–1999, 2000–2004, 2005–2009), the adjusted period prevalences of HIV, including the untested, were 13.5%, 11.6% and 7.1%, compared with the observed prevalence in the tested of 6.0%, 6.8 and 8.0%. The estimated prevalence in the untested was 33.4%, 21.6% and 6.1% in the three survey periods. CONCLUSION: The simple model was able to estimate HIV prevalence where a DSS provided mortality data for untested residents. |
format | Online Article Text |
id | pubmed-5396574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-53965742017-05-04 Adjusting the HIV prevalence for non‐respondents using mortality rates in an open cohort in northwest Tanzania Tenu, Filemon Isingo, Raphael Zaba, Basia Urassa, Mark Todd, Jim Trop Med Int Health Hiv&aids OBJECTIVE: To estimate HIV prevalence in adults who have not tested for HIV using age‐specific mortality rates and to adjust the overall population HIV prevalence to include both tested and untested adults. METHODS: An open cohort study was established since 1994 with demographic surveillance system (DSS) and five serological surveys conducted. Deaths from Kisesa DSS were used to estimate mortality rates and 95% confidence intervals by HIV status for 3‐ 5‐year periods (1995–1999, 2000–2004, and 2005–2009). Assuming that mortality rates in individuals who did not test for HIV are similar to those in tested individuals, and dependent on age, sex and HIV status and HIV, prevalence was estimated. RESULTS: In 1995–1999, mortality rates (per 1000 person years) were 43.7 (95% CI 35.7–53.4) for HIV positive, 2.6 (95% CI 2.1–3.2) in HIV negative and 16.4 (95% CI 14.4–18.7) in untested. In 2000–2004, mortality rates were 43.3 (95% CI 36.2–51.9) in HIV positive, 3.3 (95% CI 2.8–4.0) in HIV negative and 11.9 (95% CI 10.5–13.6) in untested. In 2005–2009, mortality rates were 30.7 (95% CI 24.8–38.0) in HIV positive, 4.1 (95% CI 3.5–4.9) in HIV negative and 5.7 (95% CI 5.0–6.6) in untested residents. In the three survey periods (1995–1999, 2000–2004, 2005–2009), the adjusted period prevalences of HIV, including the untested, were 13.5%, 11.6% and 7.1%, compared with the observed prevalence in the tested of 6.0%, 6.8 and 8.0%. The estimated prevalence in the untested was 33.4%, 21.6% and 6.1% in the three survey periods. CONCLUSION: The simple model was able to estimate HIV prevalence where a DSS provided mortality data for untested residents. John Wiley and Sons Inc. 2014-06 2014-03-21 /pmc/articles/PMC5396574/ /pubmed/24655037 http://dx.doi.org/10.1111/tmi.12304 Text en © 2014 The Authors. Tropical Medicine & International Health Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Hiv&aids Tenu, Filemon Isingo, Raphael Zaba, Basia Urassa, Mark Todd, Jim Adjusting the HIV prevalence for non‐respondents using mortality rates in an open cohort in northwest Tanzania |
title | Adjusting the HIV prevalence for non‐respondents using mortality rates in an open cohort in northwest Tanzania |
title_full | Adjusting the HIV prevalence for non‐respondents using mortality rates in an open cohort in northwest Tanzania |
title_fullStr | Adjusting the HIV prevalence for non‐respondents using mortality rates in an open cohort in northwest Tanzania |
title_full_unstemmed | Adjusting the HIV prevalence for non‐respondents using mortality rates in an open cohort in northwest Tanzania |
title_short | Adjusting the HIV prevalence for non‐respondents using mortality rates in an open cohort in northwest Tanzania |
title_sort | adjusting the hiv prevalence for non‐respondents using mortality rates in an open cohort in northwest tanzania |
topic | Hiv&aids |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396574/ https://www.ncbi.nlm.nih.gov/pubmed/24655037 http://dx.doi.org/10.1111/tmi.12304 |
work_keys_str_mv | AT tenufilemon adjustingthehivprevalencefornonrespondentsusingmortalityratesinanopencohortinnorthwesttanzania AT isingoraphael adjustingthehivprevalencefornonrespondentsusingmortalityratesinanopencohortinnorthwesttanzania AT zababasia adjustingthehivprevalencefornonrespondentsusingmortalityratesinanopencohortinnorthwesttanzania AT urassamark adjustingthehivprevalencefornonrespondentsusingmortalityratesinanopencohortinnorthwesttanzania AT toddjim adjustingthehivprevalencefornonrespondentsusingmortalityratesinanopencohortinnorthwesttanzania |