Inhibition of the platelet-derived growth factor receptor beta (PDGFRB) using gene silencing, crenolanib besylate, or imatinib mesylate hampers the malignant phenotype of mesothelioma cell lines

Malignant pleural mesothelioma (MPM) is a cancer of the pleural cavity resistant to chemotherapy. The identification of novel therapeutic targets is needed to improve its poor prognosis. Following a review of literature and a screening of specimens we found that platelet-derived growth factor recept...

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Detalles Bibliográficos
Autores principales: Melaiu, Ombretta, Catalano, Calogerina, De Santi, Chiara, Cipollini, Monica, Figlioli, Gisella, Pellè, Lucia, Barone, Elisa, Evangelista, Monica, Guazzelli, Alice, Boldrini, Laura, Sensi, Elisa, Bonotti, Alessandra, Foddis, Rudy, Cristaudo, Alfonso, Mutti, Luciano, Fontanini, Gabriella, Gemignani, Federica, Landi, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396622/
https://www.ncbi.nlm.nih.gov/pubmed/28435517
http://dx.doi.org/10.18632/genesandcancer.129

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