A blockade of PD-L1 produced antitumor and antimetastatic effects in an orthotopic mouse pancreatic cancer model via the PI3K/Akt/mTOR signaling pathway

BACKGROUND: Pancreatic cancer is one of the most aggressive and intractable malignant tumors, and most deaths from pancreatic cancer are related to metastases. It has been demonstrated in vitro that overexpression of programmed death-ligand 1 (PD-L1) correlates with a lack of phosphatase and tensin...

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Detalles Bibliográficos
Autores principales: Zhao, Lei, Li, Cheng, Liu, Fei, Zhao, Yonghong, Liu, Jun, Hua, Ye, Liu, Jinyang, Huang, Jiapeng, Ge, Chunlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396961/
https://www.ncbi.nlm.nih.gov/pubmed/28442920
http://dx.doi.org/10.2147/OTT.S130481

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