Editing of misaminoacylated tRNA controls the sensitivity of amino acid stress responses in Saccharomyces cerevisiae

Amino acid starvation activates the protein kinase Gcn2p, leading to changes in gene expression and translation. Gcn2p is activated by deacylated tRNA, which accumulates when tRNA aminoacylation is limited by lack of substrates or inhibition of synthesis. Pairing of amino acids and deacylated tRNAs...

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Detalles Bibliográficos
Autores principales: Mohler, Kyle, Mann, Rebecca, Bullwinkle, Tammy J., Hopkins, Kyle, Hwang, Lin, Reynolds, Noah M., Gassaway, Brandon, Aerni, Hans-Rudolf, Rinehart, Jesse, Polymenis, Michael, Faull, Kym, Ibba, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397148/
https://www.ncbi.nlm.nih.gov/pubmed/28168297
http://dx.doi.org/10.1093/nar/gkx077

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