Positive feedback loop mediated by protein phosphatase 1α mobilization of P-TEFb and basal CDK1 drives androgen receptor in prostate cancer

P-TEFb (CDK9/cyclin T) plays a central role in androgen receptor (AR)-mediated transactivation by phosphorylating both RNA polymerase 2 complex proteins and AR at S81. CDK9 dephosphorylation mobilizes P-TEFb from an inhibitory 7SK ribonucleoprotein complex, but mechanisms targeting phosphatases to P...

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Detalles Bibliográficos
Autores principales: Liu, Xiaming, Gao, Yanfei, Ye, HuiHui, Gerrin, Sean, Ma, Fen, Wu, Yiming, Zhang, Tengfei, Russo, Joshua, Cai, Changmeng, Yuan, Xin, Liu, Jihong, Chen, Shaoyong, Balk, Steven P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397168/
https://www.ncbi.nlm.nih.gov/pubmed/28062857
http://dx.doi.org/10.1093/nar/gkw1291

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