Efficient DNA binding of NF-κB requires the chaperone-like function of NPM1

NPM1/nucleophosmin is frequently overexpressed in various tumors, although the oncogenic role of NPM1 remains unclear. Here we revealed the link between NPM1 and nuclear factor-κB (NF-κB), a master regulator of inflammation. We found that NPM1 knockdown decreased NF-κB-mediated transcription of sele...

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Detalles Bibliográficos
Autores principales: Lin, Jianhuang, Kato, Mitsuyasu, Nagata, Kyosuke, Okuwaki, Mitsuru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397172/
https://www.ncbi.nlm.nih.gov/pubmed/28003476
http://dx.doi.org/10.1093/nar/gkw1285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397172/
https://www.ncbi.nlm.nih.gov/pubmed/28003476
http://dx.doi.org/10.1093/nar/gkw1285

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