Binding site density enables paralog-specific activity of SLM2 and Sam68 proteins in Neurexin2 AS4 splicing control

SLM2 and Sam68 are splicing regulator paralogs that usually overlap in function, yet only SLM2 and not Sam68 controls the Neurexin2 AS4 exon important for brain function. Herein we find that SLM2 and Sam68 similarly bind to Neurexin2 pre-mRNA, both within the mouse cortex and in vitro. Protein domai...

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Detalles Bibliográficos
Autores principales: Danilenko, Marina, Dalgliesh, Caroline, Pagliarini, Vittoria, Naro, Chiara, Ehrmann, Ingrid, Feracci, Mikael, Kheirollahi-Chadegani, Mahsa, Tyson-Capper, Alison, Clowry, Gavin J, Fort, Philippe, Dominguez, Cyril, Sette, Claudio, Elliott, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397175/
https://www.ncbi.nlm.nih.gov/pubmed/27994030
http://dx.doi.org/10.1093/nar/gkw1277

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