PHF1 Tudor and N-terminal domains synergistically target partially unwrapped nucleosomes to increase DNA accessibility

The Tudor domain of human PHF1 recognizes trimethylated lysine 36 on histone H3 (H3K36me3). PHF1 relies on this interaction to regulate PRC2 methyltransferase activity, localize to DNA double strand breaks and mediate nucleosome accessibility. Here, we investigate the impact of the PHF1 N-terminal d...

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Detalles Bibliográficos
Autores principales: Gibson, Matthew D., Gatchalian, Jovylyn, Slater, Andrew, Kutateladze, Tatiana G., Poirier, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397176/
https://www.ncbi.nlm.nih.gov/pubmed/28082396
http://dx.doi.org/10.1093/nar/gkw1320

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