Modulation of the splicing regulatory function of SRSF10 by a novel compound that impairs HIV-1 replication

We recently identified the 4-pyridinone-benzisothiazole carboxamide compound 1C8 as displaying strong anti-HIV-1 potency against a variety of clinical strains in vitro. Here we show that 1C8 decreases the expression of HIV-1 and alters splicing events involved in the production of HIV-1 mRNAs. Altho...

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Detalles Bibliográficos
Autores principales: Shkreta, Lulzim, Blanchette, Marco, Toutant, Johanne, Wilhelm, Emmanuelle, Bell, Brendan, Story, Benjamin A., Balachandran, Ahalya, Cochrane, Alan, Cheung, Peter K., Harrigan, P. Richard, Grierson, David S., Chabot, Benoit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397194/
https://www.ncbi.nlm.nih.gov/pubmed/27928057
http://dx.doi.org/10.1093/nar/gkw1223

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