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The cytokine expression in synovial membrane and the relationship with pain and pathological findings at hip arthroscopy

BACKGROUND: Synovial membrane inflammation is the most common finding presenting during hip arthroscopy, and may play a role in hip pain. We sought to determine the relationships between synovial cytokine levels, hip pain, and arthroscopic findings of the hip joint. METHODS: We prospectively include...

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Autores principales: Fukushima, Kensuke, Inoue, Gen, Fujimaki, Hisako, Uchida, Kentaro, Miyagi, Masayuki, Nagura, Naoshige, Uchiyama, Katsufumi, Takahira, Naonobu, Takaso, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397395/
https://www.ncbi.nlm.nih.gov/pubmed/28425031
http://dx.doi.org/10.1186/s40634-017-0086-4
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author Fukushima, Kensuke
Inoue, Gen
Fujimaki, Hisako
Uchida, Kentaro
Miyagi, Masayuki
Nagura, Naoshige
Uchiyama, Katsufumi
Takahira, Naonobu
Takaso, Masashi
author_facet Fukushima, Kensuke
Inoue, Gen
Fujimaki, Hisako
Uchida, Kentaro
Miyagi, Masayuki
Nagura, Naoshige
Uchiyama, Katsufumi
Takahira, Naonobu
Takaso, Masashi
author_sort Fukushima, Kensuke
collection PubMed
description BACKGROUND: Synovial membrane inflammation is the most common finding presenting during hip arthroscopy, and may play a role in hip pain. We sought to determine the relationships between synovial cytokine levels, hip pain, and arthroscopic findings of the hip joint. METHODS: We prospectively included 33 patients who underwent arthroscopic hip surgery (34 hips). For all patients, radiographs and severity of pain were evaluated preoperatively. During arthroscopy, we classified the chondral injury and synovitis, noted the incidence of labral tear and its instability, and a sample of the synovial membrane was harvested for quantitative PCR to determine levels of TNFα, IL1β, IL6, ADAMTS4, MMP1, and MMP3. The relationships between the levels of these cytokines, severity of hip pain, and the pathological findings during arthroscopy were examined. RESULTS: Pain intensity and cytokine levels were not significantly different between patients with labral tear or instability and those without. By contrast, the expression of TNFα, IL1β, IL6, and MMP1 mRNA was significantly higher in patients with diffuse synovitis than in patients with focal synovitis. VAS score during rest showed significant positive correlation with IL6 (r = 0.45, p < 0.01), while VAS score on walking showed a positive correlation with TNFα (r = 0.47, p < 0.01), and ADAMTS4 (r = 0.51, p < 0.01). The modified Harris Hip pain score showed a negative correlation with TNFα (r = −0.38, p = 0.04) and IL6 (r = −0.58, p < 0.01). CONCLUSIONS: The severity of synovitis and chondral injury are considered to be more important in the pathology of hip pain than labral tear or instability. Inflammatory cytokines, especially TNFα and IL6 might play an important role in the pathogenesis of pain in patients indicated for hip arthroscopy, possibly depending on the severity of synovitis.
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spelling pubmed-53973952017-05-05 The cytokine expression in synovial membrane and the relationship with pain and pathological findings at hip arthroscopy Fukushima, Kensuke Inoue, Gen Fujimaki, Hisako Uchida, Kentaro Miyagi, Masayuki Nagura, Naoshige Uchiyama, Katsufumi Takahira, Naonobu Takaso, Masashi J Exp Orthop Research BACKGROUND: Synovial membrane inflammation is the most common finding presenting during hip arthroscopy, and may play a role in hip pain. We sought to determine the relationships between synovial cytokine levels, hip pain, and arthroscopic findings of the hip joint. METHODS: We prospectively included 33 patients who underwent arthroscopic hip surgery (34 hips). For all patients, radiographs and severity of pain were evaluated preoperatively. During arthroscopy, we classified the chondral injury and synovitis, noted the incidence of labral tear and its instability, and a sample of the synovial membrane was harvested for quantitative PCR to determine levels of TNFα, IL1β, IL6, ADAMTS4, MMP1, and MMP3. The relationships between the levels of these cytokines, severity of hip pain, and the pathological findings during arthroscopy were examined. RESULTS: Pain intensity and cytokine levels were not significantly different between patients with labral tear or instability and those without. By contrast, the expression of TNFα, IL1β, IL6, and MMP1 mRNA was significantly higher in patients with diffuse synovitis than in patients with focal synovitis. VAS score during rest showed significant positive correlation with IL6 (r = 0.45, p < 0.01), while VAS score on walking showed a positive correlation with TNFα (r = 0.47, p < 0.01), and ADAMTS4 (r = 0.51, p < 0.01). The modified Harris Hip pain score showed a negative correlation with TNFα (r = −0.38, p = 0.04) and IL6 (r = −0.58, p < 0.01). CONCLUSIONS: The severity of synovitis and chondral injury are considered to be more important in the pathology of hip pain than labral tear or instability. Inflammatory cytokines, especially TNFα and IL6 might play an important role in the pathogenesis of pain in patients indicated for hip arthroscopy, possibly depending on the severity of synovitis. Springer Berlin Heidelberg 2017-04-20 /pmc/articles/PMC5397395/ /pubmed/28425031 http://dx.doi.org/10.1186/s40634-017-0086-4 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Fukushima, Kensuke
Inoue, Gen
Fujimaki, Hisako
Uchida, Kentaro
Miyagi, Masayuki
Nagura, Naoshige
Uchiyama, Katsufumi
Takahira, Naonobu
Takaso, Masashi
The cytokine expression in synovial membrane and the relationship with pain and pathological findings at hip arthroscopy
title The cytokine expression in synovial membrane and the relationship with pain and pathological findings at hip arthroscopy
title_full The cytokine expression in synovial membrane and the relationship with pain and pathological findings at hip arthroscopy
title_fullStr The cytokine expression in synovial membrane and the relationship with pain and pathological findings at hip arthroscopy
title_full_unstemmed The cytokine expression in synovial membrane and the relationship with pain and pathological findings at hip arthroscopy
title_short The cytokine expression in synovial membrane and the relationship with pain and pathological findings at hip arthroscopy
title_sort cytokine expression in synovial membrane and the relationship with pain and pathological findings at hip arthroscopy
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397395/
https://www.ncbi.nlm.nih.gov/pubmed/28425031
http://dx.doi.org/10.1186/s40634-017-0086-4
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