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Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III

PURPOSE: White light cystoscopy (WLC) is the standard procedure for visualising non-muscle invasive bladder cancer (NMIBC). However, WLC can fail to detect all cancerous lesions, and outcomes with transurethral resection of the bladder differ between institutions, controlled trials, and possibly bet...

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Autores principales: Bach, Thorsten, Bastian, Patrick J., Blana, Andreas, Kaminsky, Angelika, Keller, Stefan, Knoll, Thomas, Lang, Christoph, Promnitz, Soeren, Ubrig, Burkhard, Keller, Thomas, Qvick, Bryan, Burger, Maximilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397437/
https://www.ncbi.nlm.nih.gov/pubmed/27578233
http://dx.doi.org/10.1007/s00345-016-1925-0
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author Bach, Thorsten
Bastian, Patrick J.
Blana, Andreas
Kaminsky, Angelika
Keller, Stefan
Knoll, Thomas
Lang, Christoph
Promnitz, Soeren
Ubrig, Burkhard
Keller, Thomas
Qvick, Bryan
Burger, Maximilian
author_facet Bach, Thorsten
Bastian, Patrick J.
Blana, Andreas
Kaminsky, Angelika
Keller, Stefan
Knoll, Thomas
Lang, Christoph
Promnitz, Soeren
Ubrig, Burkhard
Keller, Thomas
Qvick, Bryan
Burger, Maximilian
author_sort Bach, Thorsten
collection PubMed
description PURPOSE: White light cystoscopy (WLC) is the standard procedure for visualising non-muscle invasive bladder cancer (NMIBC). However, WLC can fail to detect all cancerous lesions, and outcomes with transurethral resection of the bladder differ between institutions, controlled trials, and possibly between trials and routine application. This noninterventional study assessed the benefit of hexaminolevulinate blue light cystoscopy (HALC; Hexvix(®), Ipsen Pharma GmbH, Germany) plus WLC versus WLC alone in routine use. METHODS: From May 2013 to April 2014, 403 patients with suspected NMIBC were screened from 30 German centres to perform an unprecedented detailed assessment of the additional detection of cancer lesions with HALC versus WLC alone. RESULTS: Among the histological results for 929 biopsy samples, 94.3 % were obtained from suspected cancerous lesions under either WLC or HALC: 59.5 % were carcinoma tissue and 40.5 % were non-cancerous tissue. Of all cancer lesions, 62.2 % were staged as Ta, 20.1 % as T1, 9.3 % as T2, 7.3 % as carcinoma in situ (CIS), and 1.2 % were unknown. Additional cancer lesions (+6.8 %) and CIS lesions (+25 %, p < 0.0001) were detected by HALC plus WLC versus WLC alone. In 10.0 % of patients, ≥1 additional positive lesion was detected with HALC, and 2.2 % of NMIBC patients would have been missed with WLC alone. No adverse events were observed. CONCLUSIONS: The results of this study demonstrate that HALC significantly improves the detection of NMIBC versus WLC alone in routine clinical practice in Germany. While this benefit is statistically significant across all types of NMIBC, it seems most relevant in CIS.
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spelling pubmed-53974372017-05-04 Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III Bach, Thorsten Bastian, Patrick J. Blana, Andreas Kaminsky, Angelika Keller, Stefan Knoll, Thomas Lang, Christoph Promnitz, Soeren Ubrig, Burkhard Keller, Thomas Qvick, Bryan Burger, Maximilian World J Urol Original Article PURPOSE: White light cystoscopy (WLC) is the standard procedure for visualising non-muscle invasive bladder cancer (NMIBC). However, WLC can fail to detect all cancerous lesions, and outcomes with transurethral resection of the bladder differ between institutions, controlled trials, and possibly between trials and routine application. This noninterventional study assessed the benefit of hexaminolevulinate blue light cystoscopy (HALC; Hexvix(®), Ipsen Pharma GmbH, Germany) plus WLC versus WLC alone in routine use. METHODS: From May 2013 to April 2014, 403 patients with suspected NMIBC were screened from 30 German centres to perform an unprecedented detailed assessment of the additional detection of cancer lesions with HALC versus WLC alone. RESULTS: Among the histological results for 929 biopsy samples, 94.3 % were obtained from suspected cancerous lesions under either WLC or HALC: 59.5 % were carcinoma tissue and 40.5 % were non-cancerous tissue. Of all cancer lesions, 62.2 % were staged as Ta, 20.1 % as T1, 9.3 % as T2, 7.3 % as carcinoma in situ (CIS), and 1.2 % were unknown. Additional cancer lesions (+6.8 %) and CIS lesions (+25 %, p < 0.0001) were detected by HALC plus WLC versus WLC alone. In 10.0 % of patients, ≥1 additional positive lesion was detected with HALC, and 2.2 % of NMIBC patients would have been missed with WLC alone. No adverse events were observed. CONCLUSIONS: The results of this study demonstrate that HALC significantly improves the detection of NMIBC versus WLC alone in routine clinical practice in Germany. While this benefit is statistically significant across all types of NMIBC, it seems most relevant in CIS. Springer Berlin Heidelberg 2016-08-30 2017 /pmc/articles/PMC5397437/ /pubmed/27578233 http://dx.doi.org/10.1007/s00345-016-1925-0 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Bach, Thorsten
Bastian, Patrick J.
Blana, Andreas
Kaminsky, Angelika
Keller, Stefan
Knoll, Thomas
Lang, Christoph
Promnitz, Soeren
Ubrig, Burkhard
Keller, Thomas
Qvick, Bryan
Burger, Maximilian
Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III
title Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III
title_full Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III
title_fullStr Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III
title_full_unstemmed Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III
title_short Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III
title_sort optimised photodynamic diagnosis for transurethral resection of the bladder (turb) in german clinical practice: results of the noninterventional study optic iii
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397437/
https://www.ncbi.nlm.nih.gov/pubmed/27578233
http://dx.doi.org/10.1007/s00345-016-1925-0
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