Cargando…
Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III
PURPOSE: White light cystoscopy (WLC) is the standard procedure for visualising non-muscle invasive bladder cancer (NMIBC). However, WLC can fail to detect all cancerous lesions, and outcomes with transurethral resection of the bladder differ between institutions, controlled trials, and possibly bet...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397437/ https://www.ncbi.nlm.nih.gov/pubmed/27578233 http://dx.doi.org/10.1007/s00345-016-1925-0 |
_version_ | 1783230249476030464 |
---|---|
author | Bach, Thorsten Bastian, Patrick J. Blana, Andreas Kaminsky, Angelika Keller, Stefan Knoll, Thomas Lang, Christoph Promnitz, Soeren Ubrig, Burkhard Keller, Thomas Qvick, Bryan Burger, Maximilian |
author_facet | Bach, Thorsten Bastian, Patrick J. Blana, Andreas Kaminsky, Angelika Keller, Stefan Knoll, Thomas Lang, Christoph Promnitz, Soeren Ubrig, Burkhard Keller, Thomas Qvick, Bryan Burger, Maximilian |
author_sort | Bach, Thorsten |
collection | PubMed |
description | PURPOSE: White light cystoscopy (WLC) is the standard procedure for visualising non-muscle invasive bladder cancer (NMIBC). However, WLC can fail to detect all cancerous lesions, and outcomes with transurethral resection of the bladder differ between institutions, controlled trials, and possibly between trials and routine application. This noninterventional study assessed the benefit of hexaminolevulinate blue light cystoscopy (HALC; Hexvix(®), Ipsen Pharma GmbH, Germany) plus WLC versus WLC alone in routine use. METHODS: From May 2013 to April 2014, 403 patients with suspected NMIBC were screened from 30 German centres to perform an unprecedented detailed assessment of the additional detection of cancer lesions with HALC versus WLC alone. RESULTS: Among the histological results for 929 biopsy samples, 94.3 % were obtained from suspected cancerous lesions under either WLC or HALC: 59.5 % were carcinoma tissue and 40.5 % were non-cancerous tissue. Of all cancer lesions, 62.2 % were staged as Ta, 20.1 % as T1, 9.3 % as T2, 7.3 % as carcinoma in situ (CIS), and 1.2 % were unknown. Additional cancer lesions (+6.8 %) and CIS lesions (+25 %, p < 0.0001) were detected by HALC plus WLC versus WLC alone. In 10.0 % of patients, ≥1 additional positive lesion was detected with HALC, and 2.2 % of NMIBC patients would have been missed with WLC alone. No adverse events were observed. CONCLUSIONS: The results of this study demonstrate that HALC significantly improves the detection of NMIBC versus WLC alone in routine clinical practice in Germany. While this benefit is statistically significant across all types of NMIBC, it seems most relevant in CIS. |
format | Online Article Text |
id | pubmed-5397437 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-53974372017-05-04 Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III Bach, Thorsten Bastian, Patrick J. Blana, Andreas Kaminsky, Angelika Keller, Stefan Knoll, Thomas Lang, Christoph Promnitz, Soeren Ubrig, Burkhard Keller, Thomas Qvick, Bryan Burger, Maximilian World J Urol Original Article PURPOSE: White light cystoscopy (WLC) is the standard procedure for visualising non-muscle invasive bladder cancer (NMIBC). However, WLC can fail to detect all cancerous lesions, and outcomes with transurethral resection of the bladder differ between institutions, controlled trials, and possibly between trials and routine application. This noninterventional study assessed the benefit of hexaminolevulinate blue light cystoscopy (HALC; Hexvix(®), Ipsen Pharma GmbH, Germany) plus WLC versus WLC alone in routine use. METHODS: From May 2013 to April 2014, 403 patients with suspected NMIBC were screened from 30 German centres to perform an unprecedented detailed assessment of the additional detection of cancer lesions with HALC versus WLC alone. RESULTS: Among the histological results for 929 biopsy samples, 94.3 % were obtained from suspected cancerous lesions under either WLC or HALC: 59.5 % were carcinoma tissue and 40.5 % were non-cancerous tissue. Of all cancer lesions, 62.2 % were staged as Ta, 20.1 % as T1, 9.3 % as T2, 7.3 % as carcinoma in situ (CIS), and 1.2 % were unknown. Additional cancer lesions (+6.8 %) and CIS lesions (+25 %, p < 0.0001) were detected by HALC plus WLC versus WLC alone. In 10.0 % of patients, ≥1 additional positive lesion was detected with HALC, and 2.2 % of NMIBC patients would have been missed with WLC alone. No adverse events were observed. CONCLUSIONS: The results of this study demonstrate that HALC significantly improves the detection of NMIBC versus WLC alone in routine clinical practice in Germany. While this benefit is statistically significant across all types of NMIBC, it seems most relevant in CIS. Springer Berlin Heidelberg 2016-08-30 2017 /pmc/articles/PMC5397437/ /pubmed/27578233 http://dx.doi.org/10.1007/s00345-016-1925-0 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Bach, Thorsten Bastian, Patrick J. Blana, Andreas Kaminsky, Angelika Keller, Stefan Knoll, Thomas Lang, Christoph Promnitz, Soeren Ubrig, Burkhard Keller, Thomas Qvick, Bryan Burger, Maximilian Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III |
title | Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III |
title_full | Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III |
title_fullStr | Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III |
title_full_unstemmed | Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III |
title_short | Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III |
title_sort | optimised photodynamic diagnosis for transurethral resection of the bladder (turb) in german clinical practice: results of the noninterventional study optic iii |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397437/ https://www.ncbi.nlm.nih.gov/pubmed/27578233 http://dx.doi.org/10.1007/s00345-016-1925-0 |
work_keys_str_mv | AT bachthorsten optimisedphotodynamicdiagnosisfortransurethralresectionofthebladderturbingermanclinicalpracticeresultsofthenoninterventionalstudyopticiii AT bastianpatrickj optimisedphotodynamicdiagnosisfortransurethralresectionofthebladderturbingermanclinicalpracticeresultsofthenoninterventionalstudyopticiii AT blanaandreas optimisedphotodynamicdiagnosisfortransurethralresectionofthebladderturbingermanclinicalpracticeresultsofthenoninterventionalstudyopticiii AT kaminskyangelika optimisedphotodynamicdiagnosisfortransurethralresectionofthebladderturbingermanclinicalpracticeresultsofthenoninterventionalstudyopticiii AT kellerstefan optimisedphotodynamicdiagnosisfortransurethralresectionofthebladderturbingermanclinicalpracticeresultsofthenoninterventionalstudyopticiii AT knollthomas optimisedphotodynamicdiagnosisfortransurethralresectionofthebladderturbingermanclinicalpracticeresultsofthenoninterventionalstudyopticiii AT langchristoph optimisedphotodynamicdiagnosisfortransurethralresectionofthebladderturbingermanclinicalpracticeresultsofthenoninterventionalstudyopticiii AT promnitzsoeren optimisedphotodynamicdiagnosisfortransurethralresectionofthebladderturbingermanclinicalpracticeresultsofthenoninterventionalstudyopticiii AT ubrigburkhard optimisedphotodynamicdiagnosisfortransurethralresectionofthebladderturbingermanclinicalpracticeresultsofthenoninterventionalstudyopticiii AT kellerthomas optimisedphotodynamicdiagnosisfortransurethralresectionofthebladderturbingermanclinicalpracticeresultsofthenoninterventionalstudyopticiii AT qvickbryan optimisedphotodynamicdiagnosisfortransurethralresectionofthebladderturbingermanclinicalpracticeresultsofthenoninterventionalstudyopticiii AT burgermaximilian optimisedphotodynamicdiagnosisfortransurethralresectionofthebladderturbingermanclinicalpracticeresultsofthenoninterventionalstudyopticiii AT optimisedphotodynamicdiagnosisfortransurethralresectionofthebladderturbingermanclinicalpracticeresultsofthenoninterventionalstudyopticiii |